a-f: Family pedigrees with segregation patterns of substitutions identified in Jordanian families with young-onset parkinsonism. c The P416R mutation is present as homozygous in both affected of family G. An asterisk shows parkin Q34R segregation. e In family I the S419P mutation is present in homozygous state in both affected together with the putative polymorphisms D391D and N521. a-f Substitutions presented in the pedigrees. The A340T, E476K and N521T substitutions could be discussed, regarding mutational load and effect on disease development. An accumulation of substitutions are observed in some of the pedigrees. (N/A -Not available for DNA analysis).
Myhre et al. BMC Neurology 2008 8:47 doi:10.1186/1471-2377-8-47