Fine mapping haplotype analysis using microsatellite and SNP markers to resolve the position of a meiotic recombination in pedigree member III:8. Four SNPs from representative genes are indicated (rs10812616, rs10812615, rs17769294 and rs10122902 for C9orf11; rs2383768, rs13296489, rs1331870 and rs10968460 for LINGO2; rs2026739, rs3780473, rs10970975 and rs12985 for ACO1; rs10813831, Arg71His, rs17289927 and rs6476363 for DDX8). The informative SNP haplotypes definitively place the recombination breakpoint between D9S1118 and D9S304. The black box indicates the portion of the disease haplotype which is not shared by pedigree member III:8. Transcript map indicating the relative positions of known genes and transcripts (open boxes) (not drawn to scale).
Luty et al. BMC Neurology 2008 8:32 doi:10.1186/1471-2377-8-32