The neuropathology of patients III:2 and III:3. (A) Severe pyramidal neuronal loss from CA1 region Ammon's horn (III:2). (B) Temporal neocortex showing Aβ immunopositive plaques and cerebrovascular amyloidosis (III:2). Positive staining with ubiquitin (C-F) and TDP-43 (G-I) antibodies of neuronal cytoplasmic inclusions (NCI) in the granule cells of the dentate gyrus. Ubiquitin-positive neuronal cytoplasmic inclusions in III:2 (C, E and F) and in III:3 (D). TDP-43 positive neuronal cytoplasmic inclusions in III:2 (G and I) and III:3 (H). Bar = 50 μm in A and B; 20 μm in C and G; 10 μm in D, E, F, H and I.
Luty et al. BMC Neurology 2008 8:32 doi:10.1186/1471-2377-8-32