Table 1

Therapeutic studies of EDBP for PDPH

Author

Number of patients

Type of study

Blinding

Time window to inclusion

Follow-up

Outcome

Adverse effects


Safa-Tisseront 2001 [8]

527 (504 analyzed)

Therapeutic, prospective, non-randomised, observational

NA

4 days (1–53)

15 days

75% complete relief, 18% incomplete relief, 7% failure

Fever in 3 patients

Williams 1999 [12]

55 (7 prophylactic, 41 therapeutic EDBP, 7 conservative treatment)

Retrospective, non-randomised, observational

NA

<1 week

?

34% complete relief, 54% incomplete relief, 12% failure

Back pain in 3 patients

Banks 2001 [9]

100 (81 pdph7 prophylactic, 58 therapeutic EDBP, 23 conservative treatment)

Prospective, non randomised, observational

NA

0–3 days

?

67% complete relief, 28% incomplete relief, 5% failure

22% back pain

Taivainen 1993 [7]

81 (55 patients 10 ml, 26 patients 10–15 ml EDBP)

Prospective, partly randomised, observational

NA

0–10 days

1 week

Initial relief 91%, permanent relief 61%

25% back pain

Vercauteren 1999 [11]

190 (186 EDBP, 4 atypical symptoms)

Retrospective, non randomised

NA

>24 h after symptoms

1 day

Initial relief 99%, permanent relief 73%

?

Stride 1993 [10]

34819 (461 PDPH, 137 EDBP attempted, 135 completed)

Retrospective, non randomised

NA

2 days

?

Initial relief 90%, permanent Relief 64%

?

Seebacher 1989 [20]

12 (6 EDBP, 6 sham treatment)

Prospective, randomised

Yes

>4 days

1 day

EDBP 83% relief sham treatment 0% relief

Back pain


Oedit et al. BMC Neurology 2005 5:12   doi:10.1186/1471-2377-5-12

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