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Strength Outcomes. Studies Comparing Deflazacort and Placebo. |
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| Study (Duration of Follow up) |
B. Angelini, 1994 (12 months) |
G. Angelini, 1995 (Not stated) |
N. Brooke, 1996 (3 months) |
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| Strength Measures |
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| Myometer (difference from baseline) |
DFZ: 1.78 +/- 2.42 kg Placebo: 0.44 +/- 1.37 kg p value: NS |
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| MRC score |
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Improvement in MRC score in both daily and alternate day groups. No numerical values given. |
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| MRC index * (difference from baseline) |
DFZ: -2.35 +/- 5.48 Placebo: -9.77 +/- 12.62 p < 0.05 |
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| Average muscle score * (difference from baseline) |
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DFZ (low): +0.18 (+/- 0.4) DFZ (high): +0.26 (+/- 0.5) Placebo: -0.1 (+/- 0.5) p < 0.0001 Standard errors imputed from p values. |
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| Functional Measures |
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| Timed gait (difference from baseline) |
DFZ: -0.46 +/- 1.66 Placebo: 2.00 +/- 2.54 p < 0.01 |
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| Timed stairs (difference from baseline) |
DFZ: -1.79 +/- 4.23 Placebo: 3.71 +/- 4.64 p < 0.01 |
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| Timed chair (difference from baseline) |
DFZ: -0.43 +/- 2.65 Placebo: 2.33 +/- 5.20 P value NS |
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| Timed Gower (difference from baseline) |
DFZ: 1.81 +/- 7.18 Placebo: 3.33 +/- 7.18 P value NS |
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| Graded gait ** (difference from baseline) |
DFZ: 0.53 +/- 0.62 Placebo: 1.00 +/- 0.89 P value NS |
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| Graded stairs ** (difference from baseline) |
DFZ: -1.79 +/- 4.23 Placebo: 1.27 +/- 1.01 p < 0.01 |
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| Graded chair ** (difference from baseline) |
DFZ: 0.00 +/- 1.00 Placebo: 1.00 +/- 1.41 p < 0.05 |
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| Graded Gower ** (difference from baseline) |
DFZ: 0.12 +/- 0.78 Placebo: 1.00 +/- 1.18 p < 0.02 |
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| Other Measures |
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| Time to loss of ambulation |
DFZ: 33.2 +/- 9 m Placebo: 20.5 +/- 11 m p < 0.005 |
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A dash represents that this outcome measure was not used. MRC = Medical Research Council * For MRC score, MRC index and muscle score higher scores are more favorable. ** For Graded scores a lower score is more favorable. | |||
Campbell and Jacob BMC Neurology 2003 3:7 doi:10.1186/1471-2377-3-7 |
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