Open Access Research article

NQO1 gene rs1800566 variant is not associated with risk for multiple sclerosis

José A G Agúndez1, Elena García-Martín2, Carmen Martínez3, Julián Benito-León456, Jorge Millán-Pascual7, Patricia Calleja5, María Díaz-Sánchez5, Diana Pisa8, Laura Turpín-Fenoll7, Hortensia Alonso-Navarro9, Lucía Ayuso-Peralta10, Dolores Torrecillas10, José Francisco Plaza-Nieto9 and Félix Javier Jiménez-Jiménez109*

Author Affiliations

1 Department of Pharmacology, University of Extremadura, Cáceres, Spain

2 Department of Biochemistry and Molecular Biology, University of Extremadura, Cáceres, Spain

3 Department of Pharmacology, University of Extremadura, Badajoz, Spain

4 CIBERNED,Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain

5 Service of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain

6 Department of Medicine, University Complutense, Madrid, Spain

7 Section of Neurology, Hospital La Mancha-Centro, Alcázar de San Juan, Ciudad Real, Spain

8 Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Facultad de Ciencias, Universidad Autónoma, Cantoblanco, Madrid 28049, Spain

9 Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, Madrid, Spain

10 Department of Medicine-Neurology, Hospital “Príncipe de Asturias”, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain

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BMC Neurology 2014, 14:87  doi:10.1186/1471-2377-14-87

Published: 23 April 2014

Abstract

Background

A possible role of oxidative stress in the pathogenesis of multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis has been suggested. The detoxification enzyme NAD(P)H dehydrogenase, quinone 1 (NQO1) has been found up-regulated in MS lesions. A previous report described an association between the SNP rs1800566 in the NQO1 gene and the risk for MS in the Greek population. The aim of this study was to replicate a possible influence of the. SNP rs1800566 in the NQO1 gene in the risk for MS in the Spanish Caucasian population.

Methods

We analyzed allelic and genotypic frequency of NQO1 rs1800566 in 290 patients with MS and 310 healthy controls, using TaqMan Assays.

Results

NQO1 rs1800566 allelic and genotypic frequencies did not differ significantly between MS patients and controls, and were unrelated with age of onset of MS, gender, and clinical type of MS.

Conclusions

Our results indicate that NQO1 rs1800566 does not have an effect on MS disease risk.

Keywords:
Multiple sclerosis; Genetics; Genetic polymorphisms; NQO1; Risk factors