Positivity to p-ANCA in patients with status epilepticus
1 Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy
2 Regional Epilepsy Centre, Bianchi-Melacrino-Morelli Hospital, Reggio Calabria, Italy
3 Institute of Neurology, University Magna Graecia - Catanzaro, Italy
BMC Neurology 2014, 14:148 doi:10.1186/1471-2377-14-148Published: 17 July 2014
Status epilepticus (SE) may occur in the setting of several internal or neurologic diseases. Anti-neutrophilic cytoplasmic antibodies (ANCA) are a group of Ig that may be observed in patients with different autoimmune disorders but are particularly associated with systemic vasculitis named ANCA-associated-vasculities (AAV). We herein report 3 patients with SE and positivity to p-ANCA.
One patient had a catastrophic evolution and died 5 months after disease onset. The other two patients had a good outcome and remained seizure-free at 30 months and 5 years of follow-up respectively.
This report highlights the importance of considering ANCA dosage in patients with SE of unclear origin.