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Open Access Case report

Positivity to p-ANCA in patients with status epilepticus

Edoardo Ferlazzo12, Antonio Gambardella13*, Marina Bellavia12, Sara Gasparini12, Laura Mumoli13, Angelo Labate13, Vittoria Cianci2, Concetta Russo2 and Umberto Aguglia12

Author Affiliations

1 Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy

2 Regional Epilepsy Centre, Bianchi-Melacrino-Morelli Hospital, Reggio Calabria, Italy

3 Institute of Neurology, University Magna Graecia - Catanzaro, Italy

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BMC Neurology 2014, 14:148  doi:10.1186/1471-2377-14-148

Published: 17 July 2014



Status epilepticus (SE) may occur in the setting of several internal or neurologic diseases. Anti-neutrophilic cytoplasmic antibodies (ANCA) are a group of Ig that may be observed in patients with different autoimmune disorders but are particularly associated with systemic vasculitis named ANCA-associated-vasculities (AAV). We herein report 3 patients with SE and positivity to p-ANCA.

Case presentation

One patient had a catastrophic evolution and died 5 months after disease onset. The other two patients had a good outcome and remained seizure-free at 30 months and 5 years of follow-up respectively.


This report highlights the importance of considering ANCA dosage in patients with SE of unclear origin.

Vasculitis; Seizures; p-ANCA; Epilepsy; Status epilepticus; Death