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Open Access Research article

Lack of association between cathepsin D C224T polymorphism and Alzheimer’s disease risk: an update meta-analysis

Cuiju Mo, Qiliu Peng, Jingzhe Sui, Jian Wang, Yan Deng, Li Xie, Taijie Li, Yu He, Xue Qin* and Shan Li*

Author Affiliations

Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China

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BMC Neurology 2014, 14:13  doi:10.1186/1471-2377-14-13

Published: 15 January 2014



Cathepsin D C224T polymorphism has been reported to associate with AD susceptibility. But the results were inconsistent. This study aimed to assess the relationship between C224T polymorphism and AD risk.


The relevant studies were identified by searching PubMed, Embase, Web of Science, Google Scholar and Wan fang electronic databases updated on July 2013. The relationship between Cathepsin D C224T polymorphism and AD risk was evaluated by ORs and 95% CIs.


A total of 25 case-control studies including 5,602 cases and 11,049 controls were included in the meta-analysis. There was no association between C224T polymorphism and AD risk with all the studies were pooled in the meta-analysis (CT vs. CC: OR = 1.125, 95% CI = 0.974-1.299, P = 0.109; CT + TT vs. CC: OR = 1.136, 95% CI = 0.978-1.320, P = 0.094). Furthermore, when stratified by ethnicity, age of onset and APOEϵ4 status, significant association did not found in all subgroups.


The present meta-analysis suggested that the Cathepsin D C224T polymorphism was not associated with AD susceptibility.

Cathepsin D; AD; Polymorphism; Meta-analysis