Table 4

Results from log-linear models (binomial function), OR and 95%CI
Core analysis Both sexes Both sexes Women Men
Study population, incidence period All ages both sexes Age at onset <35y Age at onset ≥35y Age at onset ≥35y Age at onset ≥35y
First author and reference Lorraine 1990-2002 1 1 1 1 1
Debouverie 2007 [31]
Reggio Emilia 85-1989 0.33 0.37 0.25 0.28 0.18
Guidetti 1995 [36] (0.24-0.45) (0.29-0.48) (0.17-0.36) (0.19-0.42) (0.09-0.37)
UK cohort 1993-2000 1.22 0.57 1.66 1.59 1.55
Alonso 2007 [48] (0.94-1.59) (0.48-0.66) (1.30-2.13) (1.28-1.96) (1.03-2.35)
Catania 1990-1999 0.98 0.90 0.87 0.84 0.90
Nicoletti 2005 [32] (0.72-1.32) (0.72-1.12) (0.63-1.20) (0.61-1.17) 0.53-1.50)
Faroe Islands 86-2007 0.94 0.83 0.91 0.80 1.02
Joensen 2011 [19] (0.63-1.39) (0.55-1.25) (0.57-1.48) (0.45-1.45) (0.49-2.10)
Västerbotten 88-1997 1.07 1.03 1.00 0.96 1.02
Sundström 2003 [37] (0.79-1.46) (0.81-1.32) (0.72-1.39) (0.68-1.36) (0.61-1.70)
Ferrara 90-2003 0.74 0.79 0.64 0.74 0.49
Granieri 2007 [34] (0.55-0.99) (0.65-0.97) (0.48-0.86) (0.55-0.98) (0.29-0.81)
San Marino 90-2005 1.44 1.43 1.19 1.34 0.81
Granieri 2008 [35] (0.93-2.23) (0.92-2.23) (0.66-2.15) (0.71-2.54) (0.25-2.61)
Catania 2000-2004 1.39 1.19 1.43 1.06 2.07
Nicoletti 2011 [10] (1.01-1.91) (0.90-1.57) (1.01-2.00) (0.72-1.57) (1.26-3.38)
West Indies 1992-2007 0.21 0.19 0.21 0.26 0.11
Cabre 2009 [8] (0.16-0.29) (0.15-0.25) (0.15-0.29) (0.19-0.35) (0.06-0.22)
Age-groups 0-14y 0.01 0.01 - - -
(0.008-0.02) (0.008-0.02)
15-24y 0.50 0.47 - - -
(0.39-0.64) (0.42-0.52)
25-34y 1 1 - - -
35-44y 0.84 - 1 1 1
(0.67-1.04)
45-54y 0.56 - 0.66 0.61 0.71
(0.44-0.71) (0.55-0.78) (0.52-0.71) (0.52-0.97)
55-64y 0.19 - 0.21 0.17 0.29
(0.14-0.25) (0.17-0.27) (0.14-0.22) (0.20-0.44)
≥65y 0.02 - 0.02 0.02 0.03
(0.01-0.04) (0.01-0.04) (0.01-0.04) (0.01-0.06)
Sex (reference men) 2.19 2.81 1.96 - -
(1.87-2.57) (2.51-3.14) (1.67-2.31)
Mid time point incidence period * 1.09 1.06 1.12 1.07 1.20
(1.04-1.15) (1.01-1.12) (1.05-1.20) (0.99-1.15) (1.07-1.34)
Latitude degrees* 1.04 1.03 1.05 1.04 1.06
(1.03-1.05) (1.02-1.04) (1.03-1.06) (1.02-1.05) (1.03-1.08)
Diagnostic criteria* Poser 1 1 1 1 1
Other than Poser’s (McAlpine) MRI data not considered 0.73 0.71 0.77 0.59 0.99
(0.41-1.30) (0.40-1.26) (0.35-1.67) (0.25-1.41) (0.25-3.87)
McDonald or Poser and MacDonald including MRI evidence of spread 0.68 0.43 0.94 1.06 0.76
(0.55-0.85) (0.35-0.53) (0.71-1.22) (0.80-1.41) (0.49-1.26)

*Models including the variables indicated in results but not the survey place/time variable.

Alcalde-Cabero et al.

Alcalde-Cabero et al. BMC Neurology 2013 13:58   doi:10.1186/1471-2377-13-58

Open Data