Table 2

LINGO1 genotype and allelic variants of patients with multiple sclerosis (MS) and healthy volunteers
MS PATIENTS (N = 293, 586 ALLELES) CONTROLS (N = 318, 636 ALLELES) Intergroup comparison values MS WOMEN (N = 203, 406 ALLELES) CONTROL WOMEN (N = 221, 442 ALLELES) Intergroup comparison values MS MEN (N = 90, 180 ALLELES) CONTROL MEN (N = 97, 194 ALLELES) Intergroup comparison values
rs9652490 GENOTYPE A/A 197 (67.2%) 222 (69.8%) 139 (68.5%) 153 (69.2%) 58 (64.4%) 69 (71.1%)
A/G 92 (31.4%) 86 (27.0%) P = 0.197 62 (30.5%) 60 (27.1%) P = 0.170 30 (33.3%) 26 (26.8%) P = 0.651 *
G/G 4 (1.4%) 10 (3.1%) 2 (1.0%) 8 (3.6%) 2 (2.2%) 2 (2.1%)
Allele A 486 (82.9%) 530 (83.3%) -- 340 (83.7%) 366 (82.8%) -- 146 (81.1%) 164 (84.5%) --
Allele G 100 (17.1%) 106 (16.7%) OR (95% CI) 66 (16.3%) 76 (17.2%) OR (95% CI) 34 (18.9%) 30 (15.5%) OR (95% CI)
1.03 (0.76-1.39) 0.94 (0.65-1.34) 1.27 (0.74-2.18)
P = 0.853 P = 0.715 P = 0.380
rs11856808 GENOTYPE C/C 137 (46.8%) 145 (45.6%) 95 (46.8%) 101 (45.7%) 42 (46.7%) 44 (45.4%
C/T 126 (43.0%) 149 (46.9%) P = 0.407 90 (44.3%) 103 (46.6%) P = 0.852 36 (40.0%) 46 (47.4%) P = 0.313
T/T 30 (10.2%) 24 (7.5%) 18 (8.9%) 17 (7.7%) 12 (13.3%) 7 (7.2%)
Allele C 400 (68.3%) 439 (69.0%) -- 280 (69.0%) 305 (69.0%) -- 120 (66.7%) 134 (69.1%) --
Allele T 186 (31.7%) 197 (31.0%) OR (95% CI) 126 (31.0%) 137 (31.0%) OR (95% CI) 60 (33.3%) 60 (30.9%) OR (95% CI)
1.04 (0.81-1.32) 1.00 (0.75-1.34) 1.08 (0.60-1.43)
P = 0.773 P = 0.990 P = 0.725

P values correspond to 3x2 contingency tables (exact test). * Fisher’s exact test.

García-Martín et al.

García-Martín et al. BMC Neurology 2013 13:34   doi:10.1186/1471-2377-13-34

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