Open Access Research article

LINGO1 rs9652490 and rs11856808 polymorphisms are not associated with risk for multiple sclerosis

Elena García-Martín1*, Oswaldo Lorenzo-Betancor23, Carmen Martínez4, Pau Pastor235, Julián Benito-León567, Jorge Millán-Pascual8, Patricia Calleja6, María Díaz-Sánchez6, Diana Pisa9, Laura Turpín-Fenoll8, Hortensia Alonso-Navarro10, Lucía Ayuso-Peralta11, Dolores Torrecillas11, Elena Lorenzo2, José Francisco Plaza-Nieto10, José A G Agúndez4 and Félix Javier Jiménez-Jiménez1011

Author affiliations

1 Department of Biochemistry and Molecular Biology, University of Extremadura, Cáceres, SPAIN

2 Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra, Pamplona, SPAIN

3 Department of Neurology, Clínica Universidad de Navarra, University of Navarra School of Medicine, Pamplona, SPAIN

4 Department of Pharmacology, University of Extremadura, Cáceres, SPAIN

5 CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain

6 Service of Neurology, Hospital Universitario Doce de Octubre, Madrid, SPAIN

7 Department of Medicine, University Complutense, Madrid, SPAIN

8 Section of Neurology, Hospital La Mancha-Centro, Alcázar de San Juan, Ciudad Real, SPAIN

9 Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Facultad de Ciencias, Universidad Autónoma, Cantoblanco, Madrid, 28049, SPAIN

10 Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, Madrid, SPAIN

11 Department of Medicine-Neurology, Hospital “Príncipe de Asturias”, Universidad de Alcalá, Alcalá de Henares, Madrid, SPAIN

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Citation and License

BMC Neurology 2013, 13:34  doi:10.1186/1471-2377-13-34

Published: 10 April 2013



Some recent experimental data suggest a possible role of LINGO-1 in the pathogenesis of multiple sclerosis (MS). In an attempt to identify genetic biomarkers related to MS susceptibility, we genotyped two common SNPs in the LINGO1 gene which have been associated to other neurological conditions, in patients with MS and in healthy subjects. These SNPs are linked to several SNPs within the LINGO1 gene, especially in individuals of Oriental or Caucasian descent.


We analyzed the allelic and genotype frequency of two LINGO1 variants (rs9652490 and rs11856808) in 293 patients with MS and 318 healthy controls, using KASPar assays.


LINGO1 rs9652490 and rs11856808 allelic and genotype frequencies did not differ significantly between MS patients and controls. The minor allele frequencies for rs9652490 were 0.171 (95% CI = 0.140-0.201) and 0.167 (95% CI = 0.138-0.196 for cases and controls respectively (p = 0.853). For rs11856808 the minor allele frequencies were 0.317 (95% CI = 0.280-0.355) and 0.310 (95% CI = 0.274-0.346) for cases and controls, respectively (p = 0.773). Allele and genotype frequencies were unrelated with the age of onset of MS, gender, and clinical course of MS. In addition, haplotype analyses did not reveal any putative risk related to haplotypes.


These results suggest that LINGO1 rs9652490 and rs11856808 polymorphisms are not related with risk for MS. This study adds to other published evidence indicating that, to date, the LINGO1 SNPs studied here could be useful risk biomarkers of developing essential tremor, but not other movement disorders.

Multiple sclerosis; Genetics; Genetic polymorphisms; LINGO-1; Risk factors