Quantitative assessment of immunohistochemical staining in GNE myopathy. The serial stainings as in Figure 3 were quantitatively assessed in all GNE myopathy samples. A) Percentages of all fibres positive for markers of degeneration, inflammation and cell stress in GNE myopathy (left panel, note the highest values for αB-crystallin and iNOS). Subtype analysis of fibres positive for αB-crystallin and iNOS (both panels on the right). Data presented as mean plus SEM. B) Correlation analysis of fibres positive for αB-crystallin, NCAM, MHC-I and iNOS by immunohistochemical staining demonstrates a significant association between these markers.
Fischer et al. BMC Neurology 2013 13:24 doi:10.1186/1471-2377-13-24