mRNA-Expression of markers of inflammation, degeneration, regeneration and pro-inflammatory cell stress. The mRNA-expression relative to GAPDH was quantified in all GNE myopathy samples compared to non-myopathic controls. The mean expression of APP, NCAM, MHC-I, TNF-α and TGF-β is higher in GNE myopathy compared to controls, but no statistical significance is reached.
Fischer et al. BMC Neurology 2013 13:24 doi:10.1186/1471-2377-13-24