Table 1

Impact of prevalence and bias on agreement (kappa) between administrative case definitions and medical records
Comorbidity Case definition Comparison to medical records Prevalence index Bias index Adjusted kappa
No. years of data No. and type of claimsa Sens (95% CI) Spec (95% CI) Observed kappa (95% CI)
Omnibus (Any Mental) 2 ≥ 1 H or ≥ 5 P OR (≥ 1 P AND ≥ 4 Rx) 63.5 (54.0, 72.2) 86.8 (82.1, 90.6) 0.51 (0.41, 0.60) 0.42 0.01 0.60
Any Mood or anxiety disorder 2 ≥ 1 H or ≥ 5 P OR (≥ 1 P AND ≥ 4 Rx) 62.8 (53.2, 71.7) 86.9 (82.2, 90.6) 0.50 (0.41, 0.60) 0.43 0.01 0.60
Depression 2 ≥ 1 H or ≥ 5 P OR (≥ 1 P AND ≥ 7 Rx) 62.2 (52.4, 71.2) 86.7 (82.2, 90.4) 0.49 (0.40, 0.59) 0.45 0 0.60
Bipolar disorder 5 ≥ 1 H or ≥ 3P OR (≥ 1 P AND ≥ 3 Rx) 75.0 (19.4, 99.4) 97.5 (95.5, 99.4) 0.30 (0.036, 0.57) 0.95 0.02 0.94
Anxiety 2 ≥ 1 H or ≥ 2 P OR (≥ 1 P AND ≥ 2 Rx) 42.3 (23.3, 63.1) 82.2 (78.0, 85.9) 0.23 (0.022, 0.23) 0.74 0.12 0.69
Schizophrenia 2 ≥ 1 H or ≥ 2 P 1.0 (15.8, 100) 0.99 (98.6, 100) 1.0 (0, 1.0) 0.99 0 1.0

Marrie et al.

Marrie et al. BMC Neurology 2013 13:16   doi:10.1186/1471-2377-13-16

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