ROC curve resulting from the logistic regression model. The area under the curve (AUC = 0.81) shows the sensitivity and specificity corresponding to different cut-off points of the prediction of clinical worsening (defined by patients reaching the threshold of EDSS 3.5). The best cut-off point defined by the maximum of Youden’s index corresponds to a sensitivity of 0.738 and a specificity of 0.693.
Margaritella et al. BMC Neurology 2012 12:80 doi:10.1186/1471-2377-12-80