Table 3

Use of pain-related medications among study subjects*

Patients with painful neuropathies (N = 31,688)

Comparison group (N = 31,688)

P-Value


Number receiving


Antiepileptic drugs

3,838 (12.1)

283 (0.9)

<0.01


Benzodiazepines

4,127 (13.0)

1,546 (4.9)

<0.01


Corticosteroids

3,297 (10.4)

1,563 (4.9)

<0.01


Nonsteroidal anti- inflammatory drugs


Cyclooxygenase-2 inhibitors

730 (2.3)

209 (0.7)

<0.01


Other nonsteroidal anti- inflammatory drugs

17,597 (55.5)

6,946 (21.9)

<0.01


Any of above

17,902 (56.5)

7,059 (22.3)

<0.01


Muscle relaxants

422 (1.3)

70 (0.2)

<0.01


Sedatives/hypnotics

1,548 (4.9)

749 (2.4)

<0.01


Opioids


Short-acting opioids

15,587 (49.2)

4,369 (13.8)

<0.01


Long-acting opioids

719 (2.3)

66 (0.2)

<0.01


Any of above

15,674 (49.5)

4,388 (13.8)

<0.01


Antidepressants


Tricyclic antidepressants

6,320 (19.9)

477 (1.5)

<0.01


Monoamine oxidase inhibitors

12 (0.0)

7 (0.0)

0.25


Selective serotonin reuptake inhibitors

3,397 (10.7)

2,259 (7.1)

<0.01


Other antidepressants

999 (3.2)

523 (1.7)

<0.01


Any of above

9,463 (29.9)

3,038 (9.6)

<0.01


Antimigraine


Triptans

480 (1.5)

268 (0.8)

<0.01


Other antimigraine

231 (0.7)

110 (0.3)

<0.01


Any of above

647 (2.0)

351 (1.1)

<0.01


Miscellaneous


Injectable analgesics

759 (2.4)

410 (1.3)

<0.01


Topical analgesics

4,258 (13.4)

2,502 (7.9)

<0.01


Other

107 (0.3)

49 (0.2)

<0.01


Any of above

4,941 (15.6)

2,896 (9.1)

<0.01


Any of above

26,265 (82.9)

13,745 (43.4)

<0.01


Number receiving

<0.01


None of the above

5,434 (17.1)

17,952 (56.7)


1 of the above

7,877 (24.9)

8,047 (25.4)


2 of the above

7,919 (25.0)

3,677 (11.6)


3 of the above

5,264 (16.6)

1,368 (4.3)


≥ 4 of above

5,194 (16.4)

644 (2.0)


Any of above

26,265 (82.9)

13,745 (43.4)

<0.01


*Unless otherwise indicated, all values are number (%).

Berger et al. BMC Neurology 2012 12:8   doi:10.1186/1471-2377-12-8

Open Data