Table 5

Mean cognitive function by follow-up time point and according to a head to head comparison between donepezil versus stimulation therapy
Groups Time points p-value1 p-value2
Baseline n = 87 4 months n = 76 8 months n = 74 12 months* n = 69
MMSE ± SD**
Stimulation therapy 22.9 ± 4.5 22.2 ± 5.1 23.0 ± 4.0 22.7 ± 4.8 0.040 0.0016
Donepezil 23.7 ± 3.7 23.8 ± 3.8 25.1 ± 3.0 23.6 ± 3.8
Clock Drawing Test ± SD**
Stimulation therapy 2.8 ± 1.3 2.9 ± 1.2 2.8 ± 1.0 2.9 ± 1.1 0.940 0.713
Donepezil 2.8 ± 1.3 2.7 ± 1.3 2.8 ± 1.2 2.9 ± 1.1
ADAS-cog ± SD**
Stimulation therapy 18.5 ± 8.7 17.9 ± 8.6 16.7 ± 8.8 17.6 ± 8.6 0.225 0.060
Donepezil 17.6 ± 5.8 15.8 ± 6.9 15.1 ± 7.9 16.7 ± 8.1

n varies due to missing values ** Standard deviation. p-value1 = Equal time trends between groups. p-value2 = Equal time trend between groups adjusted for baseline cognitive function.

Andersen et al.

Andersen et al. BMC Neurology 2012 12:59   doi:10.1186/1471-2377-12-59

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