Table 2

Oculomotor results.

Smooth pursuit gain

Saccades


0.125 Hz

0.375 Hz

Visually guided reactive

Alternating voluntary


horiz.

up

down

horiz.

up

down

L (ms)

G20

Vpk (°/s)

N30

G(N30)


CTL

0.98

0.94

0.89

0.92

0.89

0.57

245

0.91

419

62

0.96


0.91-1.02

0.75-0.98

0.61-1.02

0.55-0.98

0.46-1.00

0.26-0.77

205-323

0.87-0.98

312-473

50-79

0.94-0.99


PD-DA

0.91*

0.87

0.87

0.77*

0.54*

0.48

296*

0.88

424

48*

0.89*


0.60-.99

0.57-1.01

0.55-0.99

0.19-0.94

0.16-0.91

0.24-0.82

214-502

0.76-0.97

330-502

21-68

0.75-0.98


PD-DBS-on

0.89*

0.71*

0.77

0.74*

0.45*

0.42

268

0.88

390

28*

0.87*


0.47-.98

0.51-.95

0.53-0.97

0.31-0.95

0.11-0.83

0.22-0.79

223-424

0.78-0.93

288-501

23-70

0.81-0.93


PD-DBS-off

0.83

0.66

0.71

0.66

0.38

0.31

288

0.88

389

23+

0.82*


0.58-1.00

0.39-0.97

0.52-1.03

0.24-0.97

0.17-0.84

0.14-0.86

226-446

0.68-1.01

284-494

13-69

0.74-1.03


Median values with 5%-95%-ranges. L, latency; G20, gain of reactive saccades (RS) aimed at targets of 20° eccentricity; Vpk, peak velocity of RS with 20° amplitude (obtained by interpolation along the main sequence); N30 and G(N30), number and gain rapidly alternating back and forth gaze shifts during 30s-epoch (AVGS). *, significant differences with respect to CTL (Kruskal-Wallis-ANOVA of groups CTL, PD-DA and PD-DBS-on followed by Mann-Whitney group comparisons, Bonferroni corrected for multiple testing; all cases p < 0.005) except saccade latency of PD-DA vs. CTL (p < 0.01); note that there were no significant differences between PD-DA and PD-DBS-on. +, significant difference (p < 0.05) between PD-DBS-on and PD-DBS-off (Wilcoxon matched pairs); note that PD-DBS-off was not compared to CTL or PD-DA to avoid repeated measurements

Pinkhardt et al. BMC Neurology 2012 12:5   doi:10.1186/1471-2377-12-5

Open Data