Open Access Highly Accessed Open Badges Case report

Japanese encephalitis accompanied by cerebral venous sinus thrombosis: a case report

Min Jia12, Nian Xiong1, Jinsha Huang1, Youpei Wang1, Xiaowei Zhang1, Zhentao Zhang3, Xuebing Cao1, Zhicheng Lin45 and Tao Wang1*

Author Affiliations

1 Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan, 430022, Hubei, China

2 Department of Neurology, The Central Hospital in En Shi, 158 Wu Yang Ave, 445000, En Shi, Hubei, China

3 Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China

4 Department of Psychiatry, Harvard Medical School; Division of Alcohol and Drug Abuse, and Mailman Neuroscience Research Center, McLean Hospital, Belmont, MA, 02478, USA

5 Harvard NeuroDiscovery Center, Boston, MA, 02114, USA

For all author emails, please log on.

BMC Neurology 2012, 12:43  doi:10.1186/1471-2377-12-43

Published: 19 June 2012



Cerebral venous sinus thrombosis (CVST) is a relatively rare cerebrovascular condition which accounts for 0.5% of all strokes. Risk of CVST has been documented in patients with numerous conditions including central nervous system infections, however, Japanese encephalitis (JE, epidemic encephalitis type B) with CVST has not been reported previously.

Case Presentation

Here, we present a case of JE with CVST in a 17-year-old man. On admission, the patient was initially diagnosed as intracranial infection, and soon after, brain magnetic resonance (MR) imaging (MRI) and MR Venography (MRV) confirmed the diagnosis of CVST. Moreover, the blood JE-specific IgM antibody which proved weakly positive at first, turned positive one week later. Consequently, our patient was diagnosed as CVST accompanied by JE. Anticoagulant and anti-infective therapy were initiated, which eventually lead to gradual recovery of the patient.


To our knowledge, this is the first case report of CVST associated with JE. MRI and MRV represent a prime method for the diagnosis of CVST, while the positivity of JE virus IgM antibody, especially increased antibody levels within a short period, is of great significance to diagnose JE. The early diagnosis and timely treatment of this potentially lethal condition would improve its prognosis significantly.

Cerebral venous sinus thrombosis; Epidemic encephalitis type B; Magnetic resonance venography; Encephalitis type B-specific IgM antibody; Case report