Table 4

Summary estimates of diagnostic accuracy from non-autopsy studies, according to imaging finding and method
Imaging finding Number of studies Sample size Sensitivity (95% CI) tau2 for sensitivity Specificity (95% CI) tau2 for specificity Positive likelihood ratio (95% CI) Negative likelihood ratio (95% CI)
CT
 Global assessment 2 107 62 (50,72) 0.01 94 (1,100) 16.45 9.61 (0.01, 6410) 0.41 (0.24, 0.69)
 White matter hyperintensities 11 196 71 (53,85) 1.53 55 (44,66) 0.48 1.58 (1.26, 1.98) 0.52 (0.32, 0.85)
 Periventricular hyperintensities 3 354 49 (39,59) 0 69 (33,91) 1.48 1.57 (0.55, 4.44) 0.74 (0.45, 1.24)
 Lacunar infarcts 3 667 42 (9,85) 2.93 86 (43,98) 2.74 3.22 (0.34, 30.9) 0.66 (0.27, 1.66)
 Non-lacunar infarcts 2 1900 45 (34,56) 0 80 (68,88) 0.03 2.23 (1.34, 3.70) 0.69 (0.55, 0.87)
 General infarcts 4 381 52 (22,80) 1.66 96 (93,98) 0 12.22 (5.59, 26.7) 0.50 (0.25, 1.01)
 Basal ganglia hyperintensities 1 163 86 (78,92) - 38 (28,49) - 1.32 (1.09, 1.60) 0.38 (0.20, 0.73)
MRI
 Global assessment 4 170 69 (36,90) 1.57 86 (45,98) 3.14 4.86 (1.10, 21.5) 0.36 (0.16, 0.80)
 White matter hyperintensities 6 334 95 (87,98) 0.75 26 (12,50) 1.41 1.29 (1.01, 1.66) 0.19 (0.07, 0.48)
 Periventricular hyperintensities 7 315 92 (70,98) 3.61 24 (6,60) 4.45 1.19 (0.88, 1.63) 0.33 (0.10, 1.10)
 Lacunar infarcts 4 599 75 (40,93) 1.82 83 (58,95) 1.45 4.49 (1.87, 10.8) 0.30 (0.11, 0.82)
 Non-lacunar infarcts 4 514 53 (41,65) 0.13 91 (85,95) 0.05 6.11 (3.13, 11.9) 0.52 (0.39, 0.68)
 General infarcts 3 955 53 (36,70) 0.21 96 (94,97) 0 13.08 (7.64, 22.4) 0.49 (0.35, 0.71)
 Basal ganglia hyperintensities 4 396 77 (66,85) 0.10 78 (67,86) 0.17 3.46 (2.14, 5.60) 0.29 (0.18, 0.48)

Beynon et al.

Beynon et al. BMC Neurology 2012 12:33   doi:10.1186/1471-2377-12-33

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