Table 2

Summary estimates of diagnostic accuracy from autopsy studies, according to imaging finding and method
Imaging finding Number of studies Sample size Sensitivity (95% CI) tau2 for sensitivity Specificity (95% CI) tau2 for specificity Positive likelihood ratio (95% CI) Negative likelihood ratio (95% CI) DOR (95% CI)
CT
 White matter hyperintensities 2 84 73 (58, 84) 0 63 (46, 77) 0 1.96 (1.23, 3.12) 0.43 (0.25, 0.75) 4.5 (1.70, 12)
 Global assessment 1 32 18 (6, 41) 80 (55, 93) 0.88 (0.21, 3.73) 1.03 (0.74, 1.44) 0.9 (0.20, 4.50)
 Periventricular hyperintensities 3 31 85 (43, 98) 1.95 50 (11, 89) 2.12 1.70 (0.58, 5.05) 0.30 (0.04, 2.18) 5.6 (0.32, 100)
 Lacunar infarcts 1 96 12 (4, 29) 100 (57, 100) 1.40 (0.08, 23.74) 0.96 (0.73, 1.27) ∞ (0.14, ∞)
 Non-lacunar infarcts 2 79 70 (56, 81) 0 93 (80, 99) 0 12.75 (3.28, 49.60) 0.31 (0.20,0.48) 41 (8.20, 196)
 General infarcts 2 123 41 (5, 89) 2.8 78 (32, 96) 1.7 1.82 (0.22,15.20) 0.76 (0.25,2.30) 2.4 (0.10, 57)
MRI
 White matter hyperintensities 1 43 79 (52, 92) 28 (15, 46) 1.09 (0.76, 1.55) 0.78 (0.24, 2.49) 1.4 (0.33, 5.80)

Beynon et al.

Beynon et al. BMC Neurology 2012 12:33   doi:10.1186/1471-2377-12-33

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