Table 1
Characteristics of studies included in the met-analyses
Study Country Study Design Population Type Analyzed

Mean

Age

(years)*

 % Males Dosage/day Seizures assessed at
PHY LEV PHY LEV PHY LEV PHY LEV
Jones et al.[7] USA Obs Severe TBI 41 32 34.6 33.2 75 73 N/A 1000 mg 7 Days
Milligan et al.[12] USA Obs Supra-tentorial surgery 210 105 60 56.3 47 39 200-800 mg 500-3000 mg 7 Days & 30 Days
Lim et al.[13] USA RCT

Glioma

(Post Operative)

 8 15 48.2 42 100 60 300-400 mg 1000-3000 mg 6 months
Szaflarski[8] USA RCT TBI, SAH 18 34 42 45 72.2 76.5 5 mg/kg 2000-3000 mg 3 Days & 6 months
Taylor et al.[14] USA Obs ICH 25 60 70.2 63.3 52 40 NA 500-2000 mg Till discharge
Murphy-Human et al.[15] USA Obs SAH 297 145 57 55 30 28 NA 1000 mg 3 Days & Till discharge

Obs Observational study, RCT Randomized Controlled Trial, LEV Levetiracetam, PHY Phenytoin, TBI Traumatic brain injury, ICH Intracranial hemorrhage, SAH Subarachnoid hemorrhage.

* Mean age has been estimated wherever not directly available.

Zafar et al. BMC Neurology 2012 12:30   doi:10.1186/1471-2377-12-30

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