Table 1

Demographic and clinical characteristics
IADL PSMS
Improved/ unchanged Deteriorated Pvalue Improved/ unchanged Deteriorated Pvalue
Variable n = 383 (49%) n = 401 (51%) n = 578 (74%) n = 206 (26%)
Female gender 232 (61%) 264 (66%) 0.138 360 (62%) 136 (66%) 0.356
APOE ε4 carrier, (n=771) 257 (68%) 268 (68%) 1.000 387 (68%) 138 (68%) 1.000
Solitary living at baseline 116 (30%) 141 (35%) 0.149 184 (32%) 73 (35%) 0.343
Antihypertensives/Cardiac therapy 156 (41%) 158 (39%) 0.716 237 (41%) 77 (38%) 0.407
Anti-diabetics 19 (5%) 14 (3%) 0.374 29 (5%) 4 (2%) 0.068
Lipid-lowering agents 46 (12%) 39 (10%) 0.358 65 (11%) 20 (10%) 0.603
Estrogens 21 (5%) 35 (9%) 0.095 37 (6%) 19 (9%) 0.206
NSAIDs/Acetylsalicylic acid 116 (30%) 117 (29%) 0.755 173 (30%) 60 (29%) 0.929
Anti-depressants 91 (24%) 107 (27%) 0.366 131 (23%) 67 (33%) 0.007
Anti-psychotics 11 (3%) 20 (5%) 0.145 20 (3%) 11 (5%) 0.296
Anxiolytics/Sedatives/Hypnotics 54 (14%) 51 (13%) 0.601 70 (12%) 35 (17%) 0.094
Variable Mean ± standard deviation Pvalue Mean ± standard deviation Pvalue
Estimated age at onset, years 71.8 ± 7.2 71.9 ± 7.7 0.969 71.5 ± 7.7 72.9 ± 6.8 0.023
Age at first assessment, years 74.8 ± 7.1 75.0 ± 7.1 0.678 74.6 ± 7.4 76.0 ± 6.3 0.007
Education, years 9.3 ± 2.4 9.4 ± 2.5 0.388 9.4 ± 2.5 9.3 ± 2.5 0.755
MMSE score at baseline 21.6 ± 3.8 21.1 ± 3.8 0.116 21.8 ± 3.5 20.0 ± 4.1 <0.001
ADAS-cog score (0–70) at baseline 20.0 ± 8.9 21.4 ± 8.9 0.030 19.5 ± 8.5 24.1 ± 9.1 <0.001
IADL score at baseline 16.4 ± 5.9 15.3 ± 4.8 0.005 15.1 ± 5.3 18.1 ± 5.1 <0.001
PSMS score at baseline 7.5 ± 2.2 7.5 ± 2.1 0.969 7.4 ± 2.1 7.7 ± 2.3 0.113
Number of medications at baseline 3.0 ± 2.5 2.7 ± 2.3 0.216 2.8 ± 2.4 3.1 ± 2.4 0.101

ADAS-cog Alzheimer’s Disease Assessment Scale-cognitive subscale, APOE apolipoprotein E, IADL Instrumental Activities of Daily Living scale, MMSE Mini-Mental State Examination, NSAID non-steroidal anti-inflammatory drugs, PSMS Physical Self-Maintenance Scale.

Wattmo et al.

Wattmo et al. BMC Neurology 2012 12:134   doi:10.1186/1471-2377-12-134

Open Data