Table 3

Risk factors of Ischemic stroke and their Population Attributable Fraction based on Cox proportional hazard model*
HR 95% CI P-value PAF (%)
Model including binary variables
Age, ≥ 65 years 2.04 (1.21- 3.44) 0.007 24
Sex, male 1.93 (1.90- 3.43) 0.024 28.4
Smoking 1.73 (0.97- 3.08) 0.063 14.5
Hypertension 2.73 (1.55- 4.81) 0.001 44.7
Diabetes 2.38 (1.42- 3.99) 0.001 24.7
Chronic Kidney Disease 2.09 (1.22- 3.58) 0.007 30.8
Model including continuous variables
Age, years 1.07 (1.03-1.11) <0.001
Sex, male 1.69 (0.95-3.00) 0.072
Smoking 1.83 (1.04-3.25) 0.038
Systolic blood pressure, cmHg 1.13 (0.99-1.28) 0.075
Diastolic blood pressure, cmHg 1.51 (1.16-1.96) 0.002
Fasting plasma glucose, mmol/l 1.11 (1.03-1.20) 0.009
GFR, mL/min/1.73 m2 0.97 (0.94-0.99) 0.014

* These risk factors remained in the model through a forward stepwise method; other variables (obesity, high waist circumference, low HDL cholesterol, hypertriglyceridemia, hypercholesterolemia, intervention and family history of premature cardiovascular disease)were excluded from the model because of p < 0.2 for entry or p > 0.1 for removal. Hosmer-Lemeshow chi-square (modified version for survival data) was <20 indicating a good fitness of the model.

HR: Hazard Ratio; CI: Confidence Interval; PAF: Population Attributable Fraction; GFR: Glomerular Filtration Rate.

Fahimfar et al.

Fahimfar et al. BMC Neurology 2012 12:117   doi:10.1186/1471-2377-12-117

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