Table 2

Risk factors of stroke and their Population Attributable Fraction based on Cox proportional hazard model*
HR 95% CI P-value PAF (%)
Model including binary variables
Age, ≥ 65 years 2.03 (1.24- 3.31) 0.005 25.0
Sex, male 2.00 (1.16- 3.43) 0.012 29.7
Smoking 1.63 (0.94- 2.80) 0.081 12.9
Hypertension 3.03 (1.76- 5.22) < 0.001 48.6
Diabetes 2.18 (1.34- 3.56) 0.002 22.0
Chronic Kidney Disease 2.01 (1.22- 3.33) 0.007 29.1
Model including continuous variables
Age, year 1.08 (1.04-1.11) < 0.001
Sex, male 1.74 (1.02-2.98) 0.044
Smoking 1.75 (1.02-3.01) 0.042
Systolic blood pressure, cmHg 1.13 (1.00-1.28) 0.045
Diastolic blood pressure, cmHg 1.55 (1.21-1.98) 0.001
Fasting plasma glucose, mmol/l 1.10 (1.01-1.18) 0.021
GFR, mL/min/1.73 m2 0.97 (0.95-0.99) 0.008

* These risk factors remained in the model through a forward stepwise method; other variables (obesity, high waist circumference, low HDL cholesterol, hypertriglyceridemia, hypercholesterolemia, intervention and family history of premature cardiovascular disease) excluded from the model because of p < 0.2 for entry or p > 0.1 for removal. Hosmer-Lemeshow chi-square (modified version for survival data) was <20 indicating a good fitness of the model.

HR: Hazard Ratio; CI: Confidence Interval; PAF: Population Attributable Fraction; GFR: Glomerular Filtration Rate.

Fahimfar et al.

Fahimfar et al. BMC Neurology 2012 12:117   doi:10.1186/1471-2377-12-117

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