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Open Access Research article

Pramipexole use and the risk of pneumonia

Pierre Ernst123*, Christel Renoux1, Sophie Dell'Aniello1 and Samy Suissa13

Author Affiliations

1 Center for Clinical Epidemiology, Lady Davis Research Institute - Jewish General Hospital, 3755 Cote Ste-Catherine, Montreal, QC, H3T 1E2, Canada

2 Division of Pulmonary Medicine, Jewish General Hospital, Montreal, QC, Canada

3 Departments of Epidemiology and Biostatistics, and of Medicine, McGill University, Montreal, QC, Canada

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BMC Neurology 2012, 12:113  doi:10.1186/1471-2377-12-113

Published: 29 September 2012

Abstract

Background

Patients with Parkinson's disease have an elevated risk of pneumonia and randomized trials suggest that this risk may be increased with the dopamine agonist pramipexole. It is uncertain whether pramipexole or other dopamine agonists increase the risk of pneumonia.

Methods

We used the United Kingdom's General Practice Research Database (GPRD) to identify users of anti-parkinsonian drugs, 40–89 years of age, between 1997 and 2009. Using a nested case–control approach, all incident cases hospitalised for pneumonia were matched with up to ten controls selected among the cohort members. Rate ratios (RR) and 95% confidence intervals (CI) of pneumonia associated with current use of dopamine agonists were estimated using conditional logistic regression, adjusted for covariates.

Results

The cohort included 13,183 users of anti-parkinsonian drugs, with 1,835 newly diagnosed with pneumonia during follow-up (rate 40.9 per 1,000 per year). The rate of pneumonia was not increased with the current use of pramipexole (RR 0.76; 95% CI: 0.57-1.02), compared with no use. The use of pramipexole was not associated with an increased rate of pneumonia when compared with all other dopamine agonists collectively (RR 0.85; 95% CI: 0.62-1.17).

Conclusions

The use of pramipexole does not appear to increase the risk of pneumonia.

Keywords:
Anti-parkinsonian drugs; Drug safety; Parkinson's disease; Restless leg syndrome; Observational study