Open Access Case report

Recurrent aseptic meningitis in association with Kikuchi-Fujimoto disease: case report and literature review

Tomoko Komagamine1*, Takahide Nagashima1, Masaru Kojima2, Norito Kokubun1, Toshiki Nakamura3, Kenich Hashimoto1, Kazuhito Kimoto4 and Koichi Hirata1

Author Affiliations

1 Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi, 321-0293, Japan

2 Department of Anatomic and Diagnostic Pathology, Dokkyo Medical University, Tochigi, Japan

3 Department of Neurology, Amakusa Rehabilitation Hospital, Saitama, Japan

4 Department of Neurology, Keiju General Hospital, Ishikawa, Japan

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BMC Neurology 2012, 12:112  doi:10.1186/1471-2377-12-112

Published: 29 September 2012



Kikuchi Fujimoto disease (KFD), or histiocytic necrotising lymphadenitis, is a benign and self-limiting condition characterised by primarily affecting the cervical lymph nodes. Recurrent aseptic meningitis in association with KFD is extremely rare and remains a diagnostic challenge.

Case presentation

We report a 28-year-old man who presented 7 episodes of aseptic meningitis associated with KFD over the course of 7 years. Histopathological findings of enlarged lymph nodes led to the diagnosis of KFD. The patient’s headache and lymphadenopathy spontaneously resolved without any sequelae.


A diagnosis of KFD should be considered when enlarged cervical lymph nodes are observed in patients with recurrent aseptic meningitis. A long-term prognosis remains uncertain, and careful follow-up is preferred.

Recurrent aseptic meningitis; Kikuchi-Fujimoto disease; Histiocytic necrotising lymphadenitis; SLE