Table 1

Characteristics of the patients included in the post-hoc analysis
Patient Sex Agea(years) Surgical intervention Concomitant medication prior to surgery Surgery related concomitant medication Rotigotine dose at time of surgery (mg/24 h) Rotigotine dose following surgery (mg/24 h) Outcome of surgery
10306 Female 60 Bypass and tricuspidal reconstruction Acetylsalicylic acid 100 mg/day, fluvastatin 80 mg/day, pantoprazole sodium 40 mg/day, telmisartan 1 mg/day. No concomitant medications recorded 4 4 recovered/resolved
10311 Female 30 Abortion No concomitant medications recorded No concomitant medications recorded 2 Discontinued 17 days prior to surgery recovered/resolved
10402 Female 54 Right knee replacement Zopiclone 3.75 mg/as needed Ibuprofen 1800 mg/day after surgery 4 4 recovered/resolved with sequelae
10404 Female 63 Surgery for dislocated fracture of left distal radius Levothyroxine 100 μg/day Furosemide 20 mg/day, acemetacin 60 mg- 180 mg/day, paracetamol 4 g/day 2 2 recovered/resolved
10429 Female 58 Right hip replacement Estradiol valerate twice weekly (unknown dose), levothyroxine sodium 50 mg/day, siccaprotect 3 drops/day (unknown dose) Indometacin 75 mg/day 3 3 not recovered/resolved (osteoarthritis was considered to be ongoing)
10702 Male 64 Cardiac bypass surgery Right shoulder surgery (osteoarthritis) Angioplasty (internal carotid artery) Cardiac bypass surgery: fenofibrate 160 mg/day, serenoa repens extract 320 mg/day, Sidros 80.5 mg/day, tamsulosin 0.4 mg/day Right shoulder surgery: heparin-fraction, sodium salt (dose unknown), torasemide 10 mg/day, bisoprolol 5 mg/day, simvastatin 40 mg/day Angioplasty: no additional medication Cardiac bypass surgery: acetylsalicylic acid 100 mg/day, torasemide 10 mg/day, bisoprolol 5 mg/day, simvastatin 40 mg/day Right shoulder surgery: Ultracet (1tab/as needed), esomeprazole 20 mg/day, diclofenac 100 mg/day Angioplasty: no additional medication 2 2 Cardiac bypass surgery: recovered/resolved Right shoulder surgery: recovered/resolved Angioplasty: recovered/resolved
10708 Female 62 Hip replacement Diclofenac 150 mg/day, estradiol valerate 1 mg/day No concomitant medications recorded 3 3 recovered/resolved
10713 Female 70 Thyroid surgery Hip replacement Thyroid surgery: simvastatin 40 mg/day, carbamazepine 400 mg/day Hip replacement: simvastatin 40 mg/day. levothyroxine 75 mg/day Thyroid surgery: no concomitant medications recorded Hip replacement: no concomitant medications recorded 4 4 Thyroid surgery: recovered/resolved Hip replacement: recovered/resolved
10801 Female 49 Surgery for left lower leg fracture Calcium with vitamin D (dose unknown), risedronate sodium 35 mg/weekly, omeprazole 40 mg/day. No concomitant medications recorded 3 3 (trial medication was temporarily suspended for the surgery and later resumed) recovered/resolved
10806 Female 43 Hysterectomy Timolol 1drop/day, domperidone 20 mg/day, acetylcysteine 600 mg/day No concomitant medications recorded 4 4 recovered/resolved
10906 Female 70 Right knee replacement Lisinopril 5 mg/day, acetylsalicylic acid 100 mg/day, trospium chloride 5 mg/day, ibuprofen 600 mg/every other day. No concomitant medications recorded 4 4 resolved with sequelae
10907 Female 68 Hallux valgus surgery Propranolol 50 mg/day, bisoprolol 50 mg/day, estriol 0.5 mg/biweekly Heparin (dose unknown), ibuprofen 1800 mg/day 4 4 recovered/resolved with sequelae
10908 Female 44 Arthroscopy of right knee No concomitant medication reported Ibuprofen 600 mg/day 2 2 not recovered/not resolved
10914 Female 71 Right knee replacement Left knee replacement Right knee replacement: bisoprolol 142.5 mg/day, ramipril 1.25 mg/day Left knee replacement: bisoprolol 142.5 mg/day, ramipril 1.25 mg/day Right knee replacement: no concomitant medications recorded Left knee replacement: omeprazole 20 mg/day, enoxaparin 40 mg/day, tilidine hydrochloride 200 mg/day, indometacin 75 mg/day, metamizole 20 drops/as needed, gabapentin 900 mg/day 4 4 Right knee replacement: resolved with sequelae Left knee replacement: recovered/resolved with sequelae
10915 Female 53 Cholecystectomy Opipramol 150 mg/day, pantoprazole sodium 20 mg/day No concomitant medications recorded 0.5 0.5 recovered/resolved
11108 Female 49 Left shoulder surgery (impingement syndrome) Estradiol valerat/norgestrel (administered in monthly cycle; 21 doses over 28 days) No concomitant medications recorded 4 4 recovered/resolved
11110 Female 70 Hysterectomy Theophylline 400 mg/day, ibuprofen 400 mg/day, fluticasone propionate/salmeterol xinafoate (dose unknown), cromoglicate sodium/reproterol hydrochloride (dose unknown), allopurinol 300 mg/day No concomitant medications recorded 2 2 recovered/resolved
11112 Female 23 Submandibular cyst resection No concomitant medications recorded No concomitant medications recorded 2 2 recovered/resolved
11209 Male 47 Perianal abscess resection Diltiazem 90 mg/day, pentaerithrityl tetranitrate 80 mg/day Ibuprofen 1600 mg/day (discontinued because of an allergic reaction) thereafter tramadol 60 drops/day 3 3 recovered/resolved
11211 Male 62 Left knee replacement Candesartan cilexetil (dose unknown)/day, celecoxib 100 mg/day, doxazosin mesilate (dose unknown)/day, dyazide 1tab/day, etoricoxib 60 mg/day, ibuprofen 600 mg/day, metoprolol succinate 95 mg/day, rofecoxib (dose unknown)/day Heparin-fraction/sodium salt 2 mL /day, metamizole sodium 2000 mg/mL/day, tramadol hydrochloride 200 mg/day 4 4 (after surgery), discontinued 23 days after surgery owing to rehabilitation recovered/resolved
11405 Female 64 Surgery for lumbar spinal cord stenosis Left shoulder surgery (frozen shoulder) Surgery for lumbar spinal cord stenosis: no concomitant medications recorded Left shoulder surgery: cefuroxime 1000 mg/day. Surgery for lumbar spinal cord stenosis: no concomitant medications recorded Left shoulder surgery: no concomitant medications recorded 4 4 Surgery for lumbar spinal cord stenosis: recovered/resolved Left shoulder surgery: recovered/resolved
11408 Female 63 Vein stripping (both legs) Olmesartan medoxomil 20 mg/day Initially alfetanil, mepivacaine, midazolam, propofol (doses unknown). Thereafter ibuprofen (dose unknown) 3 3 recovered/resolved
11419 Male 45 Right shoulder surgery No concomitant medications recorded Ibuprofen 400 mg/as needed 4 4 recovered/resolved
11428 Female 76 Right thumb surgery (arthrosis metacarpophalangeal) Cyanocobalamin 1 mL/month, pantoprazole sodium 40 mg/day No concomitant medications recorded 4 4 recovered/resolved
11430 Female 60 Hallux valgus surgery No concomitant medications recorded Diclofenac 50 mg/as needed 2 2 recovered/resolved
11501 Male 74 Hip replacement Alprostadi cream 10 μg/day, candesartan cilexetil 4 mg/day, itraconazole solution (dose unknown)/day, nifedipine 10 mg/day No concomitant medications recorded 4 4 recovered/resolved
11503 Female 63 Tendon repair (supraspinatus) Captopril 17.5 mg/day, levothyroxine sodium 50 μg/day, simvastatin 20 mg/day plus unspecified pain medication No concomitant medications recorded 4 4 recovered/resolved with sequelae
11601 Female 67 Right knee replacement Acetylsalicylic acid 300 mg/day, bisoprolol (dose unknown), conjugated estrogens (dose unknown) Ibuprofen 800 mg/as needed, cortisone (dose unknown)/as needed 4 4 recovered/resolved
11608 Male 76 Surgery for salivary gland adenoma Enalapril maleate 10 mg/day, amiloride hydrochlorothiazide 5 mg/day, ramipril 5 mg/day No concomitant medications recorded 4 4 recovered/resolved with sequelae
11609 Male 66 Coronary artery disease, stent implant No concomitant medications recorded Acetylsalicylic acid 100 mg/day and blood coagulation factors 75 mg/day for 5 ½ months, thereafter asasantin 1 capsule/day; bisoprolol 5 mg/day 4 4 recovered/resolved
11612 Male 71 Surgical treatment of lipoma No information available No information available Discontinued in order to plan for surgical treatment of the lipoma Discontinued ongoing
11811 Male 64 Hand surgery (Dupuytren’s contracture) Dermatologicals 1 mg/day cream, enalapril maleate 0.5 mg/day, hydrochlorothiazide and 0.5 mg/day heparin-fraction/sodium salt 2500 IU/day (day prior to surgery) Heparin-fraction/sodium salt 2500 IU/day, ibuprofen 600 mg/as needed 3 3 recovered/resolved
11814 Male 43 Laparoscopic surgery (inguinal hernia) Ibuprofen 800 mg as needed, levothyroxine sodium/potassium iodide 75 μg/day No concomitant medications recorded 4 4 recovered/resolved
11901 Female 71 Surgical elevation of bladder Radius fracture surgery Surgical elevation of bladder: ginkgo biloba extract 80 mg/day, acetylsalicylic acid 100 mg/day, calcium compounds 1500 mg/day, bisoprolol 5 mg/day, estrogen 0.6 mg/day, omeprazole 20 mg/day, diclofenac 75 mg/prn, hypericum perforatum 1350 mg/day, losartan 50 mg/day Radius fracture surgery: acetylsalicylic acid 100 mg/day, bisoprolol 10 mg/day, bromazepam 6 mg/as needed, calcium compounds 1500 mg/day, diclofenac 75 mg/as needed, dimethindene drops 4.5 mg/day, estrogen 0.6 mg/day, furosemide 40 mg/day, ginkgo biloba extract 80 mg/day, hypericum perforatum 1350 mg/day, losartan 50 mg/day, omeprazole 20 mg/day, prednicarbate cream (dose unknown). Prior to surgery: metamizole 1000 mg/day, tilidine 100 mg/day, enoxaparin sodium 0.4 mL/day (prophylaxis of thrombosis), cefuroxime 1.5 mg/day (inflammatory prevention), bupivacaine 10 mL, mepivacaine 40 mL (anaesthesia), clorazepate dipotassium 10 mg (tranquilizer) midazolam 6 mg (sedative) Surgical elevation of bladder: enoxaparin 40 mg/day, magnesium 1500 mg/day, ethinyl estradiol 20 mg/day, promethazine 25 mg/day, midazolam 3.75 mg/day, sultamicillin 1125 mg/day. Radius fracture surgery: tilidine 100 mg/day 0.5 0.5 Surgical elevation of bladder: recovered/resolved Radius fracture surgery: recovered/resolved
11902 Female 66 Surgical elevation of bladder Esomeprazole 20 mg/day, pantoprazole 20 mg/day, methotrexate 25 mg/week, prednisolone 5 mg/day, metoprolol 25 mg/day, calcium folinate 6.35 mg/week, leflunomide 20 mg/day, nitrofurantoin 50 mg/day, vitamin C + calcium (dose unknown) Sulfamethoxazole (dose unknown) 4 4 recovered/resolved
12102 Female 59 Repair of incisional hernia Diclofenac 75 mg/as needed, ibuprofen (unknown dose)/as needed, oestradiol/norethisterone acetate (unknown dose)/day, levothyroxine sodium 50 μg/day, omeprazole 20 mg/day Certoparia sodium 9000 units/day, thereafter novaminsulfon 1 mL/day 3 3 recovered/resolved
12103 Female 56 Colon adenoma ablation Norethisterone acetate (dose unknown), estradiol (dose unknown), acetylsalicylic acid 750 mg/as needed No concomitant medications recorded 1 1 recovered/resolved
12208 Male 66 Appendectomy Acarbose 150 mg/day, amlodipine 5 mg/day, clopidogrel sulfate 75 mg/day, fenofibrate 200 mg/day, ferrous sulfate 50 mg/day, glibenclamide 7 mg/day, lisinopril 5 mg/day, simvastatin 20 mg/day No concomitant medications recorded 3 3 recovered/resolved
12307 Female 59 Right knee replacement Lumbar disk surgery Right knee replacement: diclofenac 75 mg/day (plus physiotherapy) Lumbar disk surgery: ibuprofen 600 mg/as needed, thereafter paracetamol/codeine phosphate 1560 mg/day and metamizole sodium 1500 mg/day Right knee replacement: diclofenac 150 mg/day, metamizole 1500 mg/day Lumbar disk surgery: oxycodone/naloxone 30 mg/day, tilidine drops (dose unknown)/as needed, fentanyl patch 50 μg/week 4 4 Right knee replacement: recovered/resolved with sequelae Lumbar disk surgery: recovering/resolving
12315 Male 46 Meniscus surgery Acetylsalicylic acid 100 mg/day. No concomitant medications recorded 3 3 recovered/resolved
12401 Male 66 Prostate resection Bisoprolol hemifumarate 5 mg/day, flecainide acetate 100 mg/day, lansoprazole 15 mg/day, valsartan drops 160 mg/day No concomitant medications recorded, no chemotherapy, no tumor markers 4 4 recovered/resolved
12603 Female 63 Vein stripping (both legs) Biotin 2.5 mg/week, calcium 500 mg/day, ergocalciferol 0.025 mg/day, estradiol (dose unknown), zinc 25 mg/week, unspecified other urologicals, including antispasmodics. Prior to surgery: 40 mg/day heparin fraction/sodium salt for the prevention of thrombosis No concomitant medications recorded, compression stockings recorded as therapy 2 2 recovered/resolved
12606 Male 63 Vein stripping (right leg) Acetylsalicylic acid 300 mg/day, allopurinol 300 mg/day, bisoprolol 5 mg/day, insulin 48 IU/day, metformin 850 mg/day, ramipril 1 mg/day No concomitant medications recorded 3 3 recovered/resolved
12701 Male 70 Pelvic bypass surgery Acetylsalicylic acid 200 mg/day, nafti-ratiopharm retard 400 mg/day No concomitant medications recorded 3 3 recovered/resolved with sequelae
13001 Female 72 Surgery for left orbital fracture Mesalazine 1500 mg/day, amlodipine 5 mg/day No concomitant medications recorded 4 4 recovered/resolved
13002 Female 49 Hysterectomy No concomitant medications recorded No concomitant medications recorded 4 4 recovered/resolved
13013 Female 75 Hip replacement (left) Hip replacement (right) Hip replacement (left) and hip replacement (right):valsartan/hydrochlorothiazide (dose unknown), diclofenac 100 mg/as needed and 75 mg/as needed, diclofenac potassium 50 mg/as needed, lercanidipine 10 mg/day, metoprolol (dose unknown) Hip replacement (left) and hip replacement (right): no concomitant medications recorded 0.5 0.5 Hip replacement (left): recovered/resolved Hip replacement (right): recovered/resolved
13102 Female 63 Vertebral fusion (spondylolisthesis) Vertebral fusion (spondylolisthesis) Both surgeries: lercanidipine 10 mg/day, pravastatin sodium 40 mg/day, ibuprofen 400 mg/as needed. Both surgeries: no concomitant medications recorded 4 4 Both surgeries: recovered/resolved
14007 Male 66 Osteotomy of right distal tibia Heparin-fraction/sodium salt 40 mg/day, Heparin-fraction/sodium salt 40 mg/day, naproxen 1000 mg/day, pantoprazole 20 mg/day 3 3 recovered/resolved
17005 Female 47 Hysterectomy Ibuprofen 600 mg as needed No concomitant medications recorded 3 3 recovered/resolved
17007 Female 71 Hip prosthesis replacement Chondroitin sulfate sodium 800 mg/day, glucosamine sulfate 1500 mg/day, ibuprofen 400 mg/as needed, paracetamol 600 mg/as needed Acetylsalicylic acid 300 mg/day, enoxaparin 40 mg/day, alendronate sodium 70 mg/week, calcium 500 mg/day, ciprofloxacin 1500 mg/day, paracetamol 4 g/day, metamizole 150 mg/day, omeprazole 20 mg/day, thiamine nitrate/pyridoxine hydrochloride, clonazepam 2.5 mg/day (for RLS, immediately after surgery) 4 4 recovering/resolving
17301 Male 71 Bladder resection Pentoxifylline 800 mg/day, tamsulosin 0.4 mg/day No concomitant medications recorded 4 4 recovered/resolved

a at start of open-label extension period.

Högl et al.

Högl et al. BMC Neurology 2012 12:106   doi:10.1186/1471-2377-12-106

Open Data