Table 2

Variables associated with sufficient ((25(OH)D >20ng/ml) vs insufficient (25(OH)D) <20ng/ml) plasma concentrations in RRMS patients during winter
All patients n = 40 25(OH)D >20 ng/mL n = 16 25(OH)D <20 ng/mL n = 24 p-value
Age 40 ± 7.8 40.6 ± 9.2 41.8 ± 7.05 0.5
% Female 35 (87%) 13 (92.9%) 22 (84.6%) 0.45
Years of evolution 11 ± 6.7 10.3 ± 7 12.1 ± 6.7 0.4
Number of previous relapses 6 ± 4.2 4.4 ±3.4 7.3 ± 4.2 0.08
Annualised relapse rates 0.35 ±0.2 0.4 ±0.2 0.3 ±0.2 0.2
EDSS 2.5 [1–3.5] 2.0[1.5-4.5] 3[1–5.0] 0.02
Oligoclonal bands 23 (54%) 9 (56.2%) 14 (58.3%) 0.28
HLADR15 positive 8 (21%) 4 (28.6%) 4 (15.4%) 0.3
Proliferation of T cells to myelin peptides 28 (70%) 5 (35.7%) 23 (88.5%) 0.001*
Number of lesions in T2 42.5 ± 36 30.7 ± 23.7 44 ± 38 0.4
Number of contrast- enhancing lesions 0.85 ± 2 0.4 ± 0.9 1.2 ± 2.6 0.8

* = statistically-significant; RRMS = relapsing-remitting multiple sclerosis; 25(OH)D = 25hydroxyvitamin; EDSS = expanded disability status scale.

Grau-López et al.

Grau-López et al. BMC Neurology 2012 12:103   doi:10.1186/1471-2377-12-103

Open Data