Genetic polymorphisms involved in dopaminergic neurotransmission and risk for Parkinson's disease in a Japanese population
1 Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
2 Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
3 Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
4 Department of Public Health, Osaka City University Graduate School of Medicine, Osaka, Japan
5 Department of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, Tokyo, Japan
6 Department of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
7 Clinical Research Institute and Department of Neurology, Utano National Hospital, Kyoto, Japan
8 Department of Geriatrics and Neurology, Osaka City University Graduate School of Medicine, Osaka, Japan
9 Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
10 Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
11 Department of Public Health, Saitama Medical University Faculty of Medicine, Saitama, Japan
12 Other members of the Study Group are listed in the Appendix
BMC Neurology 2011, 11:89 doi:10.1186/1471-2377-11-89Published: 25 July 2011
Parkinson's disease (PD) is characterized by alterations in dopaminergic neurotransmission. Genetic polymorphisms involved in dopaminergic neurotransmission may influence susceptibility to PD.
We investigated the relationship of catechol-O-methyltransferase (COMT), monoamine oxidase B (MAOB), dopamine receptor (DR) D2 and DRD4 polymorphisms and PD risk with special attention to the interaction with cigarette smoking among 238 patients with PD and 369 controls in a Japanese population.
Subjects with the AA genotype of MAOB rs1799836 showed a significantly increased risk of PD (odds ratio (OR) = 1.70, 95% confidence interval (CI) = 1.12 - 2.58) compared with the AG and GG genotypes combined. The AA genotype of COMT rs4680 was marginally associated with an increased risk of PD (OR = 1.86, 95% CI = 0.98 - 3.50) compared with the GG genotype. The DRD2 rs1800497 and DRD4 rs1800955 polymorphisms showed no association with PD. A COMT -smoking interaction was suggested, with the combined GA and AA genotypes of rs4680 and non-smoking conferring significantly higher risk (OR = 3.97, 95% CI = 2.13 - 7.41) than the AA genotype and a history of smoking (P for interaction = 0.061). No interactions of smoking with other polymorphisms were observed.
The COMT rs4680 and MAOB rs1799836 polymorphisms may increase susceptibility to PD risk among Japanese. Future studies involving larger control and case populations and better pesticide exposure histories will undoubtedly lead to a more thorough understanding of the role of the polymorphisms involved in the dopamine pathway in PD.