Table 4

Biochemical parameters values at baseline and following 15 weeks of double-blind treatment

PS-DHA

Placebo


Variable

Baseline (mean ± SD)

15 weeks (mean ± SD)

P value1 (within group)

Baseline (mean ± SD)

15 weeks (mean ± SD)

P value1 (within group)

P value2 (between groups)


Glucose (mg/dL)

106.6 ± 34.0

105.9 ± 37.1

0.885

103.4 ± 30.7

111.1 ± 47.3

0.082

0.175


Male

115.1 ± 42.0

110.4 ± 47.4

0.551

105.8 ± 33.6

118.3 ± 59.9

0.076

0.101


Female

98.0 ± 20.7

101.5 ± 22.5

0.330

100.6 ± 27.3

102.9 ± 25.6

0.662

0.847


Sodium (mmol/L)

140.6 ± 2.6

140.9 ± 2.7

0.316

140.9 ± 2.1

140.3 ± 2.3

0.014*

0.017*


Male

140.6 ± 2.6

140.9 ± 2.7

0.352

141.2 ± 2.0

140.6 ± 2.1

0.092

0.061


Female

140.5 ± 2.7

140.8 ± 2.7

0.582

140.6 ± 2.2

140.0 ± 2.5

0.079

0.136


Calcium (mg/dL)

9.6 ± 0.6

9.6 ± 0.5

0.452

9.4 ± 0.6

9.6 ± 0.5

0.012*

0.038*


Male

9.5 ± 0.4

9.5 ± 0.5

0.966

9.4 ± 0.3

9.5 ± 0.4

0.189

0.413


Female

9.8 ± 0.7

9.6 ± 0.5

0.371

9.5 ± 0.8

9.7 ± 0.5

0.032*

0.051


Phosphorus (mg/dL)

3.4 ± 0.6

3.3 ± 0.5

0.103

3.4 ± 0.5

3.3 ± 0.5

0.346

0.807


Male

3.2 ± 0.6

3.1 ± 0.5

0.190

3.2 ± 0.5

3.2 ± 0.5

0.636

0.671


Female

3.7 ± 0.5

3.6 ± 0.5

0.326

3.5 ± 0.6

3.4 ± 0.5

0.397

0.932


Chloride (mmol/L)

101.6 ± 3.1

102.4 ± 3.0

0.010*

101.9 ± 3.1

101.8 ± 2.3

0.880

0.047*


Male

101.9 ± 2.8

102.6 ± 3.0

0.094

102.1 ± 3.0

102.1 ± 2.2

1.000

0.262


Female

101.2 ± 3.4

102.2 ± 2.9

0.053

101.6 ± 3.4

101.5 ± 2.4

0.819

0.104


Potassium (mmol/L)

4.6 ± 0.5

4.5 ± 0.3

0.031*

4.6 ± 0.5

4.7 ± 0.7

0.703

0.128


Male

4.8 ± 0.7

4.6 ± 0.4

0.095

4.7 ± 0.4

4.7 ± 0.6

0.977

0.221


Female

4.5 ± 0.3

4.4 ± 0.3

0.173

4.6 ± 0.6

4.6 ± 0.8

0.638

0.345


BUN (mg/dL)

18.5 ± 4.9

18.9 ± 4.8

0.321

18.6 ± 5.2

19.7 ± 6.7

0.039*

0.262


Male

19.6 ± 4.8

19.9 ± 4.9

0.679

20.5 ± 5.3

21.7 ± 7.2

0.101

0.249


Female**

17.4 ± 4.9

18.0 ± 4.7

0.345

16.3 ± 4.1

17.3 ± 5.3

0.225

0.680


Creatinine (mg/dL)

0.9 ± 0.2

0.9 ± 0.2

0.223

0.9 ± 0.2

0.9 ± 0.2

0.416

0.953


Male

1.0 ± 0.2

1.0 ± 0.2

0.507

1.0 ± 0.3

1.0 ± 0.3

0.617

0.420


Female

0.8 ± 0.1

0.8 ± 0.2

0.237

0.7 ± 0.2

0.8 ± 0.2

0.041*

0.265


Alkaline Phosphatase (U/L)

68.3 ± 22.5

67.3 ± 22.6

0.331

69.9 ± 30.0

69.4 ± 27.8

0.578

0.726


Male

69.6 ± 24.9

68.0 ± 25.7

0.380

73.3 ± 36.2

72.1 ± 33.0

0.286

0.842


Female

67.1 ± 20.1

66.7 ± 19.4

0.693

66.0 ± 20.8

66.3 ± 20.3

0.862

0.724


ALT/SGPT (U/L)

23.9 ± 26.4

20.7 ± 8.4

0.282

19.3 ± 6.4

19.5 ± 5.8

0.733

0.262


Male

28.9 ± 36.3

22.3 ± 9.7

0.273

19.2 ± 5.9

19.2 ± 5.8

1.000

0.276


Female

18.9 ± 6.8

19.0 ± 6.6

0.869

19.5 ± 7.1

19.9 ± 5.8

0.655

0.794


AST/SGOT (U/L)

25.2 ± 20.8

22.4 ± 6.1

0.250

21.9 ± 6.2

21.8 ± 5.3

0.879

0.280


Male

28.6 ± 28.6

23.3 ± 7.1

0.276

21.8 ± 5.7

21.3 ± 5.5

0.536

0.329


Female

21.9 ± 6.5

21.5 ± 5.0

0.685

21.9 ± 6.8

22.3 ± 5.0

0.704

0.577


Total Bilirubin (mg/dL)

0.6 ± 0.2

0.6 ± 0.3

0.361

0.6 ± 0.3

0.6 ± 0.3

0.673

0.747


Male

0.6 ± 0.3

0.6 ± 0.3

0.097

0.7 ± 0.3

0.7 ± 0.3

0.325

0.753


Female

0.5 ± 0.2

0.5 ± 0.2

0.699

0.5 ± 0.2

0.5 ± 0.2

0.423

0.826


Total Protein (g/dL)

7.3 ± 0.4

7.3 ± 0.4

0.190

7.3 ± 0.5

7.4 ± 0.5

0.188

0.936


Male

7.3 ± 0.4

7.3 ± 0.5

0.358

7.3 ± 0.4

7.3 ± 0.5

0.990

0.489


Female

7.3 ± 0.4

7.3 ± 0.4

0.362

7.4 ± 0.6

7.5 ± 0.4

0.091

0.443


Triglycerides (mg/dL)

141.6 ± 61.4

133.0 ± 70.0

0.133

128.9 ± 54.8

131.6 ± 58.5

0.677

0.186


Male

138.2 ± 68.1

133.8 ± 79.6

0.577

131.6 ± 54.9

121.7 ± 42.2

0.198

0.611


Female

145.1 ± 54.8

132.2 ± 60.0

0.132

125.9 ± 55.4

142.8 ± 71.9

0.103

0.025*


HDL (mg/dL)

54.8 ± 12.4

56.4 ± 13.4

0.118

53.7 ± 14.1

54.4 ± 14.1

0.430

0.505


Male

48.8 ± 9.6

50.4 ± 10.5

0.044*

48.3 ± 10.2

49.2 ± 11.2

0.348

0.604


Female

60.9 ± 12.1

62.4 ± 13.4

0.404

59.9 ± 15.4

60.3 ± 14.9

0.785

0.635


LDL (mg/dL)

97.6 ± 31.4

98.6 ± 31.7

0.745

98.9 ± 30.9

99.1 ± 25.6

0.940

0.853


Male

88.6 ± 30.4

91.0 ± 31.8

0.287

94.4 ± 28.9

92.9 ± 21.2

0.656

0.332


Female

106.6 ± 30.2

106.2 ± 30.2

0.946

104.1 ± 32.8

106.2 ± 28.5

0.672

0.743


Total cholesterol (mg/dL)

177.5 ± 38.2

181.1 ± 35.2

0.402

178.0 ± 37.2

179.4 ± 33.7

0.650

0.687


Male

164.6 ± 31.2

167.6 ± 33.1

0.283

168.5 ± 33.2

166.0 ± 26.3

0.487

0.226


Female

190.3 ± 40.6

194.5 ± 32.4

0.613

188.7 ± 39.0

194.6 ± 35.1

0.284

0.856


1 Based on two-sided t test for dependent samples. 2 Based on two-sided t test for independent samples

* Statistical significance was not maintained following Bonferonni correction

In the treatment arm, 33 males and 33 females had biochemical blood measurements at baseline and endpoint.

In the placebo arm, 34 males and 30 females had biochemical blood measurements at baseline and endpoint.

** In the placebo arm 29 females had BUN measurements at baseline and endpoint.

Vakhapova et al. BMC Neurology 2011 11:79   doi:10.1186/1471-2377-11-79

Open Data