Table 1

Migraine and MTHFR case control studies

Migraine

Population

Cases

Controls

OR (95%CI)

Reference


MA

British Caucasian

124

1725

1.3 (1.01-1.70)

Current


MA

North Indian

67

150

1.295"a" (0.676-2.478)

[44]


MA

Portuguese

78

397

0.48 (0.18-1.23)

[29]


MA

Italian

100

105

2.48 (1.11-5.58)

[39]


MA, MO

Italian

105 (90 MO and 15 MA)

97

MA: 2.16 (0.64-7.41) MO: 2.04 (0.98-4.22)

[45]


MA

Italian

33 (5-17 yr old)

66 (Adults)

2.18 (0.68, 7)

[46]


MA "b"

USA Caucasian female only

1275

23726

0.79 (0.65-0.96)

[26]


MA

Japanese

22

261

6.5 (2.5-16.8)

[12]


MA, MO

Turkish

93(23 MA; 70 MO)

136

MA: 3.05 (0.39-24.51) MO: 7.44 (1.70-32.34)

[11]


MA, MO

Spanish Caucasian

230 (78 MA and 152 MO)

204

MA: 1.37 (0.63-2.94) MO: 0.59 (0.27-1.24)

[15]


MA

Australian Caucasian

168

269

2.54 (1.37-4.71)

[13]


MA, MO

Spanish Caucasian

329 (138 MA and 191 MO)

237

MA: 2.4 (0.8-7.2) MO: 0.28 (0.1-0.8)

[37]


MA

Dutch

187

1212

2.05 (1.2-3.4)

[14]


MA

German

656

625

0.87 (0.61-1.25)

[16]


MA

Finnish

898

900

0.98 (0.84-1.15) "c"

[17]


MA migraine with aura, MO migraine without aura. OR for T/T genotype of MTHFR C677T polymorphism. "a" CT genotype is the reference point. MA n = 67, 0% TT genotype, 69.9% CC, 30.1% CT. healthy controls n= 150, TT 2%, CC 72% and CT 26%.

"b" self reported migraine with aura. "c" OR for T allele frequency in cases and controls. 12.7% of cases did not fulfil criteria for MA based on the International Headache Society Criteria for MA. MA here is therefore used as a broad definition.

Samaan et al. BMC Neurology 2011 11:66   doi:10.1186/1471-2377-11-66

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