Table 1

Performance characteristics for 14-3-3, tau and S100B.

Marker

Threshold

Sea

95%CI

Spa

95% CI

LR+ a

95% CI

LR-a

95% CI


14-3-3

-

0.88

0.81-0.93

0.72

0.69-0.75

3.1

2.8-3.6

0.16

0.10-0.26

Tau

976b

0.91

0.84-0.95

0.88

0.85-0.90

7.4

6.9-7.8

0.10

0.06-0.20

1300c

0.84

0.76-0.90

0.92

0.90-0.94

10.9

8.5-13.9

0.17

0.11-0.26

S100B

2.5b

0.87

0.80-0.92

0.87

0.84-0.91

6.6

6.1-7.1

0.15

0.09-0.20

4.2c

0.52

0.42-0.61

0.97

0.95-0.98

15.3

10.2-23.1

0.50

0.42-0.60


a Se - sensitivity, Sp - specificity, LR+ - positive likelihood ratio, LR- - negative likelihood ratio.

b Optimal scoring thresholds for tau and S100B, estimated in this study. Values are in pg/mL for tau, and in ng/mL for S100B.

c Consensus scoring thresholds for tau and S100B, based on published literature.

Coulthart et al. BMC Neurology 2011 11:133   doi:10.1186/1471-2377-11-133

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