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Open Access Research article

Validation of the spanish version of the multiple sclerosis international quality of life (musiqol) questionnaire

Oscar Fernández1*, Victoria Fernández2, Karine Baumstarck-Barrau3, Luis Muñoz1, Maria del Mar Gonzalez Alvarez1, José Carlos Arrabal1, Antonio León1, Ana Alonso1, Jose Carlos López-Madrona1, Rafael Bustamante1, Gloria Luque1, Miguel Guerrero2, Elisabetta Verdun di Cantogno4, Pascal Auquier3 and the MusiQoL study group of Spain

Author Affiliations

1 Institute of Clinical Neurosciences. Service of Neurology. Hospital Regional Universitario Carlos Haya, Avda. Carlos Haya s/n, 29010 Málaga, Spain

2 Institute of Clinical Neurosciences. Service of Neurophysiology. Hospital Regional Universitario Carlos Haya, Avda. Carlos Haya s/n, 29010 Málaga, Spain

3 Department of Public Health, EA3279 Research Unit, University Hospital, Boulevard Jean Moulin, 13385 Marseille, France

4 Global Medical Affairs Neurology, Merck Serono S.A., 9 Chemin des Mines, 1202 Geneva, Switzerland

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BMC Neurology 2011, 11:127  doi:10.1186/1471-2377-11-127

Published: 18 October 2011



The Multiple Sclerosis International Quality Of Life (MusiQoL) questionnaire, a 31-item, multidimensional, self-administrated questionnaire that is available in 14 languages including Spanish, has been validated using a large international sample. We investigated the validity and reliability of the Spanish version of MusiQoL in Spain.


Consecutive patients with different types and severities of multiple sclerosis (MS) were recruited from 22 centres across Spain. All patients completed the MusiQoL questionnaire, the 36-Item Short Form (SF-36) health survey, and a symptoms checklist at baseline and 21 days later. External validity, internal consistency, reliability and reproducibility were tested.


A total of 224 Spanish patients were evaluated. Dimensions of MusiQoL generally demonstrated a high internal consistency (Cronbach's alpha: 0.70-0.92 for all but two MusiQoL domain scores). External validity testing revealed that the MusiQoL index score correlated significantly with all SF-36 dimension scores (Pearson's correlation: 0.46-0.76), reproducibility was satisfactory (intraclass correlation coefficient: 0.60-0.91), acceptability was high, and the time taken to complete the 31-item questionnaire was reasonable (mean [standard deviation]: 9.8 [11.8] minutes).


The Spanish version of the MusiQoL questionnaire appears to be a valid and reliable instrument for measuring quality of life in patients with MS in Spain and constitutes a useful instrument to measure health-related quality of life in the clinical setting.