Table 3

Predictors of cognitive impairment at Year 3, defined as impaired performance on ≥3 cognitive tests (multivariate logistic regression)

Odds ratio

95% CI


Stable/increased T2 lesion volume over 3 years

Treatment with sc IFN β-1a 44 µg tiw

0.45

0.23-0.91

Baseline BH lesion volume

1.01

1.00-1.01

Number of new T2 lesions

1.13

1.02-1.26


Stable/increased BH volume over 3 years

Treatment with sc IFN β-1a 44 µg tiw

0.46

0.23-0.92

ESS score at baseline

0.82

0.69-0.98

Presence of new BH over 3 years

3.21

1.52-6.75


Three or more impaired cognitive tests at Year 3

Baseline T2 lesion volume

1.01

1.00-1.01

Verbal IQ*

0.92

0.87-0.98

IFN β-1a, 44 μg sc tiw

0.31

0.10-0.98


CI, confidence interval; IFN, interferon; IQ, intelligence quotient; sc, subcutaneously; tiw, three times weekly.

*Higher score denotes superior outcome.

Bastianello et al. BMC Neurology 2011 11:125   doi:10.1186/1471-2377-11-125

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