Table 1

Change in MRI parameters from baseline to Year 3 (pooled treatment groups)

MRI Parameter


T2 lesions

T1 Gd+ lesions

T1 black holes


Lesion volume, mm3

Baseline

Year 3

Baseline

Year 3

Baseline

Year 3

N

158

158

154

154

156

156

Mean (SD)

5990.1 (7111.6)

5345.9 (6755.3)

73.8 (252.1)

25.6 (125.5)

1263.1 (2430.6)

1185.4 (2520.7)

Median

3378.5

2825.0

0.0

0.0

436.3

341.9

Q1, Q3

1052.9, 7358.5

782.0, 6918.5

0.0, 0.0

0.0, 0.0

76.5, 1189.2

67.9, 1160.0

Absolute change, mm3

N

158

154

156

Mean (SD)

−644.2 (3072.1)

−48.2 (269.3)*

−77.7 (1056.8)

Median

−135.6

0.0

0.0

Q1, Q3

−719.8, 86.7

0.0, 0.0

−89.5, 73.4

Percentage change

N

158

34

132

Mean (SD)

−7.6 (34.1)c

−60.5 (149.4)

0.3 (67.8)

Median

−7.3

−100.0

−4.7

Q1, Q3

−23.8, 4.0

−100.0, −100.0

−32.1, 19.5


Gd+, gadolinium-enhancing; IFN, interferon.

*P = 0.0034 vs baseline; Wilcoxon signed rank test.

Percentage change was not calculated for patients with a lesion volume of 0 mm3 at baseline.

P < 0.0001 vs baseline; Wilcoxon signed rank test.

Bastianello et al. BMC Neurology 2011 11:125   doi:10.1186/1471-2377-11-125

Open Data