Recurrent myelitis after allogeneic stem cell transplantation. Report of two cases
Hertie Institute for Clinical Brain Research, Department of General Neurology, University of Tübingen, Hoppe-Seyler-Strasse 3, 72076 Tübingen, Germany
BMC Neurology 2010, 10:76 doi:10.1186/1471-2377-10-76Published: 1 September 2010
Allogeneic and autologous haematopoietic stem cell transplantation are established treatment options for haematological malignancies and may possibly be employed to treat a range of genetic and autoimmune diseases.
We report two patients who developed an acute myelitis within their thoracic spinal cord after allogeneic stem cell transplantation. Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.
Myelitis is a possibly disabling consequence of haematopoietic stem cell transplantation.