Table 6

Efficacy outcome reporting for each included intervention

Intervention


Pregabalin

Lidocaine plaster

Duloxetine


Mean Pain Scores-No. studies (no. patients receiving the intervention)+ reporting reduction in mean pain scores compared to baseline


No. studies reporting data for any pain intensity outcome

7

3

1


McGill questionnaire

2* (109)


Pain reduction measured by VRS

2* (81)


Pain intensity measured by NRS

1* (30)

1NR (32)


Pain intensity measured by BPI

2* (73)


Pain score measured by NPS-10, NPS-8 and NPS-4

1* (71)


Pain intensity measured by present pain intensity (PPI)

1* (81)


Percentage pain score reduction

1NR (16)


Pain severity measured by VAS

1* (18)


Quality of life-No. studies (no. patients receiving the intervention)+ reporting improvements in quality of life compared to baseline


No. studies reporting data for any quality of life outcome

4

1

0


SF-MPQ total, sensory and affective score

1*


Quality of life measured by the SF-12

1* (55)


Sleep interference measured by NRS

1* (55), 1NS (30)


Quality of sleep measured by VRS

1* (28)


Quality of sleep (instrument not reported)

1* (3)


Inference of mood measured by VRS

1* (28)


Daily activity measured by VRS

1* (28)


Function interference measured by NRS

1* (30)


Psychological stress measured by the Short Questionnaire on Current Burden

1* (55)


Pain associated distress measured by NRS

1* (30)


PGIC

1* (18)


Responders-No. studies (no. patients receiving the intervention)+ reporting data for outcome


No. studies reporting data for any pain relief outcome

4

4

0


Complete pain relief

1 (53)

2 (48)


range of percentages reported

25%

13-22%


A lot of pain relief

2 (48)


range of percentages reported

25-34%


Moderate pain relief

2 (48)


range of percentages reported

33-44%


Pain reduction of ≥ 50%

3 (158)

2 (7)


range of percentages reported

33-49%

100%a


Pain reduction 10-50%

2 (105)

1 (33)


range of percentages reported

17%b

NRc


Non-responders

3 (132)

2 (52)


range of percentages reported

26-46%

6-20%


*Statistically significant; NS-not statistically significant; NR-statistical significance not reported.

+Numbers of patients receiving the intervention of interest.

aTwo case studies of 3 and 4 patients: the former reported all patients achieved 50% reduction in pain score, the latter reported improvements in all patients in an inconsistent manner.

bOne study reported that 4 of 24 patients achieved pain relief of 10-25%. The second study reported 38 out of 78 evaluable patients experienced ≥ 30% reduction in pain from baseline.

cOne study stated that patients experienced pain relief of 10%-50%, however it was unclear whether this referred to all patients.

Plested et al. BMC Neurology 2010 10:116   doi:10.1186/1471-2377-10-116

Open Data