Table 5 |
||
|
Summary of previous, concomitant and add-on therapy |
||
|
Study reference |
Previous medication |
Concomitant/add-on medication |
|
|
||
|
Pregabalin |
||
|
|
||
|
Freynhagen 2007 [27] |
Anticonvulsants (except pregabalin), Antidepressants Cannabinoids, Gabapentin, Muscle relaxants, NSAID/COX-2 inhibitor, Opioids |
Analgesics, Non-pharmacological treatment |
|
|
||
|
Obermann 2008 [33] |
Carbamazepine, Gabapentin, Oxcarbazepine |
Carbamazepine, Lamotrigine |
|
|
||
|
Sommer 2007 [34] |
Cabergoline, Gabapentin, L-DOPA, Pergolide, Pramipexole, Roprinole, Roprinole + tilidine, Tilidine |
Pramipexole + tilidine/naloxone Pramipexole + fentanyl patch |
|
|
||
|
Ambesh 2008 [24] (A) |
Current analgesic treatment regimens, Conventional pain therapies |
Amitriptyline |
|
|
||
|
Allen 2005 [26] (A) |
Gabapentin |
NR |
|
|
||
|
Tricyclics, Gabapentin |
NR |
|
|
|
||
|
Hanu-Cernat 2005 [32] (A) |
Gabapentin, Pregabalin |
NR |
|
|
||
|
Stacey 2008 [29] [linked to D'Urso De Cruz 2005; D'Urso De Cruz 2005; Siffert 2005 [42-44]] |
Anticonvulsants, Gabapentin, NSAIDs/Cox IIs, Opoid analgesics, Pregabalin, SSRI, SNRI, Tramadol, Tricyclics |
Tricyclics, Gabapentin |
|
|
||
|
Toth 2007 [30] (A) |
Gabapentin |
NR |
|
|
||
|
Lidocaine plaster |
||
|
|
||
|
Galer 1999 [22] |
Unclear; enriched enrolment design-patients either were treated with the lidocaine plaster and requested open-label use, or were refractory to previous treatment, although type of previous treatment was unclear. |
Acetaminophen, Opiates, NSAIDs, Tricyclics |
|
|
||
|
Hines 2002 [21] |
Hydrocodone/acetaminophen, NSAIDs, Sertraline, Diazepam, Rofecoxib, Oxycodone, Progesterone therapy, Gabapentin, Atenolol, Ibuprofen, Opioid analgesics, Clonidine, Citalopram, Olanzapine, Lorazepam, Cyclobenzaprine, Hormone replacement therapy, Hydrocodone, Fluoxetine, Amitriptyline, Venlafaxine, Buspirone |
Tramadol, Sustained-release diltiazem, Hormone replacement therapy, Triamterene, Amitriptyline, Sertraline, Diazepam, Rofecoxib Oxycodone controlled-release tablets, Tizanidine, Progesterone therapy, Verapamil, Clonidine, Baclofen Venlafaxine, Gabapentin |
|
|
||
|
Devers 2000 [28] |
Anticonvulsants, Eutectic mixture of local anaesthetics, Lidocaine, Mexiletine, Opoids, Prilocaine (EMLA) cream, Tricyclics |
Amitriptyline, Acetamenophen, Carbamazepine, Fentanyl patch, Gabapentin, Hydromorphone, Lamotrigine, Methadone, Nortriptyline, Oxycodone, Paroxetine. |
|
|
||
|
Robert 2005 [25](A) |
Combinations of conventional anti-neuropathic drugs: Anticonvulsants, Free radical scavengers, Ketamine, Opioids, Tricyclics. |
NR |
|
|
||
|
Argyra 2005 [35](A) |
NR |
Lidocaine was tested as an add-on therapy, although other treatments were not reported. |
|
|
||
|
Galer 2004 [20] |
Cyclo-oxygenase-2 (COX-2) inhibitors, Non-selective NSAIDs, Gabapentin, Tramadol, Opioids |
NR |
|
|
||
|
Galer 2003 [36] |
Topical lidocaine plaster |
Anticonvulsants, Acetaminophen, Conticosteroids, Opioids, Tricyclics. |
|
|
||
|
Duloxetine |
||
|
|
||
|
Restivo 2008 [23] |
NR |
NR |
|
|
||
|
Plested et al. BMC Neurology 2010 10:116 doi:10.1186/1471-2377-10-116 |
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