Table 2

Partial correlations of cystatin C and creatinine-based eGFR with inflammatory and procoagulant markers at the baseline visit of the MESA study, stratified by presence of chronic kidney disease
Marker of Kidney Function
 Inflammatory Marker


CRP
(N = 6750)
 IL-6
(N = 6622)
 TNF-αR1
(N = 995)
 ICAM-1
(N = 2611)
 Fibrinogen
(N = 6750)
 Factor VIII
(N = 6750)
Cystatin C
 0.075*
 0.156*
 0.748*
 0.209*
 0.137*
 0.112*
Creatinine-based eGFR
 -0.019
 -0.003
 -0.285*
 0.025
 -0.059*
 -0.034*
Persons with CKD





     Cystatin C
 0.116*
 0.230*
 0.903*
 0.160*
 0.248*
 0.140*
     Creatinine-based eGFR
 -0.101*
 -0.139*
 -0.763*
 -0.035
 -0.286*
 -0.146*
Persons without CKD





     Cystatin C
 0.085*
 0.180*
 0.557*†
 0.261*
 0.111*†
 0.085*
     Creatinine-based eGFR
 -0.004‡
 0.025‡
 -0.168*‡
 0.027
 -0.021‡
 0.017‡

Partial correlations adjusted for age, gender, race/ethnicity, and BMI

Chronic kidney disease (CKD) defined as eGFR < 60 mL/min/1.73 m2

* Correlation is significant at the 0.01 level (2-tailed).

† Correlation between cystatin C and the biomarker is significantly stronger among participants with CKD

‡ Correlation between creatinine-based eGFR and the biomarker is significantly stronger among participants with CKD

Keller et al. BMC Nephrology 2008 9:9   doi:10.1186/1471-2369-9-9