Table 2

Partial correlations of cystatin C and creatinine-based eGFR with inflammatory and procoagulant markers at the baseline visit of the MESA study, stratified by presence of chronic kidney disease

Marker of Kidney Function

Inflammatory Marker


CRP

(N = 6750)

IL-6

(N = 6622)

TNF-αR1

(N = 995)

ICAM-1

(N = 2611)

Fibrinogen

(N = 6750)

Factor VIII

(N = 6750)


Cystatin C

0.075*

0.156*

0.748*

0.209*

0.137*

0.112*


Creatinine-based eGFR

-0.019

-0.003

-0.285*

0.025

-0.059*

-0.034*


Persons with CKD

Cystatin C

0.116*

0.230*

0.903*

0.160*

0.248*

0.140*

Creatinine-based eGFR

-0.101*

-0.139*

-0.763*

-0.035

-0.286*

-0.146*


Persons without CKD

Cystatin C

0.085*

0.180*

0.557*†

0.261*

0.111*†

0.085*

Creatinine-based eGFR

-0.004‡

0.025‡

-0.168*‡

0.027

-0.021‡

0.017‡


Partial correlations adjusted for age, gender, race/ethnicity, and BMI

Chronic kidney disease (CKD) defined as eGFR < 60 mL/min/1.73 m2

* Correlation is significant at the 0.01 level (2-tailed).

† Correlation between cystatin C and the biomarker is significantly stronger among participants with CKD

‡ Correlation between creatinine-based eGFR and the biomarker is significantly stronger among participants with CKD

Keller et al. BMC Nephrology 2008 9:9   doi:10.1186/1471-2369-9-9

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