Table 9

Clinical and histologic differences between MPO-ANCA (+) and PR3-ANCA (+) patients

MPO-ANCA (+) N = 17

PR3-ANCA (+) N = 9

p


I. Clinical


Age (years)

63 ± 10

55 ± 17

NS

pCreatinine at biopsy (mg/dl)

5.9 ± 4.5

6.5 ± 5.3

NS

pUrea at biopsy (mg/dl)

123 ± 56

138 ± 92

NS

CRP (mg/l)

54 ± 63

84 ± 95

NS

ESR (mm/1 h)

116 ± 34

116 ± 16

NS

24 h urinary albumin excretion (g)

1.24 ± 0.81

1.04 ± 0.73

NS


II. Histologic


Crescents (%)

61 ± 35

67 ± 28

NS

Cellular crescents

56 ± 44

66 ± 46

NS

Fibrocellular crescents

13 ± 30

8 ± 17

NS

Fibrous crescents

10 ± 21

15 ± 31

NS

Obsolete glomeruli

28 ± 22

20 ± 24

NS

Focal necrosis

1.41 ± 0.5

1.22 ± 0.44

NS

TIN infiltration

1.53 ± 1.12

1.0 ± 1.15

NS

Tubular atrophy

1.4 ± 0.98

0.62 ± 0.74

NS

TIN fibrosis

1.5 ± 1.09

1.07 ± 1.09

NS

Arterial sclerosis

1.94 ± 1.0

1.5 ± 1.19

NS


Abbrev: CRP, C-reactive protein, ESR, erythrocyte sedimentation rate, TIN, tubulointerstitial

Alexopoulos et al. BMC Nephrology 2006 7:16   doi:10.1186/1471-2369-7-16

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