Table 8

Differences in immunohistochemical findings between ANCA (+) and ANCA (+) patients

ANCA (+) N = 26

ANCA (-) N = 8

p

I. Glomeruli

PCNA(+) cells

36 ± 16

26 ± 16

NS

α-SMA(+)cells

34 ± 15

32 ± 19

NS

Monocytes/macrophages

15 ± 10

14 ± 10

NS

LFA-1β(+)cells

15 ± 6

10 ± 4

NS

TGF-β1 expression

1.14 ± 0.69

2.25 ± 0.96

0.05

ICAM-1 expression

1.53 ± 0.64

2.25 ± 0.96

NS(0.06)

C5b-9 expression

2.27 ± 0.96

2.25 ± 0.5

NS

II. Tubulointerstitium

HLA-DR(+) cells

1207 ± 831

736 ± 300

NS

PCNA(+)cells

809 ± 170

581 ± 181

0.041

α-SMA(+)cells

728 ± 260

556 ± 318

NS

Monocytes/macrophages

570 ± 204

452 ± 156

NS

LFA-1β(+)cells

485 ± 149

517 ± 86

NS

ICAM-1 in tubules

34.2 ± 11.4

45.5 ± 12.5

NS

C5b-9 in tubules

32,3 ± 9,7

32,7 ± 8.16

NS

TGF-β1 in interstitium

1.73 ± 0.8

2 ± 1.41

NS

TGF-β1 in tubules

1.87 ± 0.83

2.25 ± 0.96

NS

ICAM-1in vessels

1,21 ± 0,42

1.0 ± 0.01

NS

C5b-9 in vessels

1.06 ± 0.25

1.01 ± 0.09

NS

Alexopoulos et al. BMC Nephrology 2006 7:16   doi:10.1186/1471-2369-7-16