Table 2

Number of cases and controls needed to detect a 2-fold risk (alpha 5%, 1-beta = 80%). Comparison of heavy analgesic use (top tertile in grams) vs. non use in the respective categories of analgesics. Important: the subcategories are not mutually exclusive and cannot be added up to 100%.

Prevalence in controls (%)

Nb of cases

Nb of controls


All analgesics (phenacetin-free)

22.8

104

416

Phenacetin-containing

2.5

616

2464

MONOS

Paracetamol

5.3

308

1232

ASA

15.7

129

516

Ibuprofen

2.1

728

2912

Other monos

5.0

324

1296

COMBIS

Paracetamol+caffeine

0.1

14 670

58 680

Paracetamol+ASA

0.9

1657

6628

Paracet+ASA+caffeine

4.1

388

1552

Others+caffeine

0.6

2470

9880

Other combis without caffeine

3.5

449

1800

Other combis+caffeine

3.3

475

1900

Combis with codeine or barbiturates

1.9

654

2616


Heinemann et al. BMC Nephrology 2005 6:9   doi:10.1186/1471-2369-6-9

Open Data