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Open Access Highly Accessed Case report

Progressive multifocal cerebral infarction in a young kidney transplant recipient due to thrombotic microangiopathy

Arash Haghikia12*, Meike Heeren3, Clemens Bockmeyer4, Bernd Haubitz5 and Wilfried Gwinner16

Author Affiliations

1 Center of Internal Medicine, Hannover Medical School, Hannover, Germany

2 Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany

3 Department of Neurology, Hannover Medical School, Hannover, Germany

4 Department of Pathology, Hannover Medical School, Hannover, Germany

5 Department of Neuroradiology, Hannover Medical School, Hannover, Germany

6 Department of Nephrology and Hypertensiology, Hannover Medical School, Hannover, Germany

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BMC Nephrology 2014, 15:59  doi:10.1186/1471-2369-15-59

Published: 7 April 2014

Abstract

Background

Renal transplant recipients frequently experience neurological complications. Whereas ischemic stroke, cerebral haemorrhage or hypertensive encephalopathy often result from vascular alterations prior to transplantation, other cerebral diseases like CNS infections, primary brain tumors and drug induced neurotoxicity may develop as consequences of the required post-transplant immunosuppressive treatment.

Case presentation

Here we report on an unusual clinical course of a young kidney transplant recipient with a cluster of fulminant necrotic brain lesions within a period of two months due to thrombotic microangiopathy.

Conclusion

Cerebral ischemia in organ transplant recipients should prompt one to consider thrombotic microangiopathy.

Keywords:
Cerebral infarctions; Kidney transplantation; Microangiopathy