Table 1

Baseline patient characteristics, study population n = 1015
Characteristic n All Non epo-resistant Epo-resistant
Age years 1015 66 (8) 65 (8) 67 (8)
Gender % men 1015 53.9 55 41
Systolic BP mmHg 1015 145 (22) 146 (23) 147 (23)
Diastolic BP mmHg 1015 76 (11) 76 (11) 75 (11)
BMI kg/m2 1015 27.5 (4.8) 27.6 (4.8) 26.9 (5.0)
Duration of diabetes years 953 18.1 (8.8) 17.6 (8.7) 18.5 (8.7)
Time on dialysis months 1015 8.2 (6.9) 8.6 (7.0) 7.0 (6.5)
History of
CAD % 1015 28,50 28,50 28,50
CHF % 1015 35.4 32.2 41.9
PVD % 1015 44.6 43.8 46.6
Smoker or ex-smoker % 1015 40.4 40.8 34.4
use of ACE-inhibitors % 1015 48 48 54
heart rate bpm 988 79 (15) 78 (15) 81 (17)
Laboratory parameters 253 25 0 100
ERI-Index > 10.1 (%)*
LDL cholesterol mg/dl 1015 126 (30) 126 (31) 121 (27)
AP U/I 1015 123 (63)
HDL cholesterol mg/dl 1015 36 (13) 36 (13) 37 (15)
Triglycerides mg/dl 1015 264 (167) 269 (173) 260 (172)
Hemoglobin g/dl 1015 10.9 (1.3) 11.0 (1.2) 10.3 (1.5)
Albumin g/dl 1015 3.8 (0.3) 3.8 (0.3) 3.7 (0.3)
C-reactive protein mg/l 1009 5.8 (2.3-12.4) 9.9 (15.8) 14.7 (20.8)
Calcium mmol/l 1015 2.3 (0.2) 2.3 (0.2) 2.3 (0.2)
Phosphate mg/dl 1015 6.1 (1.6) 6.1 (1.6) 6.2 (1.6)
HbA1c % 1015 6.7 (1.3) 6.7 (1.2) 6.6 (1.3)
urea mg/dl 1015 143 (36) 144 (36) 137 (35)
potassium mmol/l 1015 5.2 (0.9) 5.2 (0.8) 5.4 (1.0)
ferritin μg/L 1015 487 (426) 520 (436) 442 (405)
iron saturation % 1015 22.2 (11.3) 23.3 (11.5) 17.9 (8.7)
NT-pro-BNP pg/ml 1009 3361 (1433–9271) 7885 (14153) 9609 (14105)
Troponin T ng/ml 1009 0.09 (0.13) 0.08 (0.11) 0.11 (1.17)
ADMA umol/l 1007 0.87 (0.16) 0.86 (0.15) 0.90 (0.16)
PTH pg/mL 1008 102 (119) 101 (117) 91 (127)
25(OH)Vitamin D ng/mL 1015 17.9 (9.8) 18.2 (10.1) 16.8 (8.8)
Osteocalcin ug/l 1008 107 (102) 109 (100) 101 (100)

Values are presented as mean ± SD or percentages.

Abbreviations: CAD = coronary artery disease; CHF = congestive heart failure, PVD = peripheral vascular disease.

BMI = body-mass index, LDL = low-density lipoprotein, HDL = high-density lipoprotein.

HbA1c = glycosylated hamoglobin, NT-pro-BNP = N-terminal pro b-type natriuretic peptide.

* ESA Resistance Index.

Cut-off values: Q1 < 4.19; Q2 (4,20-6.64); Q3 (6.65 – 10.11); Q4 > 10.11.

Patients in the upper ERI quartile were defined as ESA resistant.

Schneider et al.

Schneider et al. BMC Nephrology 2013 14:67   doi:10.1186/1471-2369-14-67

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