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Open Access Research article

Renal dysfunction in STEMI-patients undergoing primary angioplasty: higher prevalence but equal prognostic impact in female patients; an observational cohort study from the Belgian STEMI registry

Sofie A Gevaert1*, Dirk De Bacquer2, Patrick Evrard3, Marc Renard4, Christophe Beauloye5, Patrick Coussement6, Herbert De Raedt7, Peter R Sinnaeve8 and Marc J Claeys9

Author Affiliations

1 Department of Cardiology, Ghent University Hospital, Ghent, Belgium

2 Department of Public Health, Ghent University, Ghent, Belgium

3 Department of Intensive Care, Université Catholique de Louvain, Yvoir, Belgium

4 Department of Cardiology, Erasme Academic Hospital, Brussels, Belgium

5 Université Catholique de Louvain, Department of Cardiology, Brussels, Belgium

6 Department of Cardiology, Hospital St. Jan, Bruges, Belgium

7 Cardiovascular centre, OLV Hospital Aalst, Aalst, Belgium

8 Department of Cardiovascular diseases, University Hospitals Leuven, Leuven, Belgium

9 Department of Cardiology, University Hospital Antwerp, Edegem, Belgium

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BMC Nephrology 2013, 14:62  doi:10.1186/1471-2369-14-62

Published: 18 March 2013

Abstract

Background

Mortality in female patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary angioplasty (pPCI) is higher than in men. We examined gender differences in the prevalence and prognostic performance of renal dysfunction at admission in this setting.

Methods

A multicenter retrospective sub-analysis of the Belgian STEMI-registry identified 1,638 patients (20.6% women, 79.4% men) treated with pPCI in 8 tertiary care hospitals (January 2007-February 2011). The estimated glomerular filtration rate (eGFR) was calculated using the CKD-EPI equation. Main outcome measure was in-hospital mortality.

Results

More women than men suffered from renal dysfunction at admission (42.3% vs. 25.3%, p < 0.001). Mortality in women was doubled as compared to men (9.5 vs. 4.7%, OR (95% CI) = 2.12 (1.36-3.32), p<0.001). In-hospital mortality for men and women with vs. without renal dysfunction was much higher (10.7 and 15.3 vs. 2.3 and 2.4%, p < 0.001). In a multivariable regression analysis, adjusting for age, gender, peripheral artery disease (PAD), coronary artery disease (CAD), hypertension, diabetes and low body weight (<67 kg), female gender was associated with renal dysfunction at admission (OR (95% CI) 1.65 (1.20-2.25), p = 0.002). In a multivariable model including TIMI risk score and renal dysfunction, renal dysfunction was an independent predictor of in-hospital mortality in both men (OR (95% CI) = 2.39 (1.27-4.51), p = 0.007) and women (OR (95% CI) = 4.03 (1.26-12.92), p = 0.02), with a comparable impact for men and women (p for interaction = 0.69).

Conclusions

Female gender was independently associated with renal dysfunction at admission in pPCI treated patients. Renal dysfunction was equally associated with higher in-hospital mortality in both men and women.

Keywords:
ST-segment elevation myocardial infarction (STEMI); Estimated glomerular filtration rate (eGFR); CKD-EPI; Renal dysfunction; Gender; In-hospital mortality; Primary angioplasty