Serum C1q- binding adiponectin in maintenance hemodialysis patients
1 Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2–2 B-5, Yamada-oka, Suita, Osaka 565-0871, Japan
2 Kishida Clinic, 5-6-3, Honmachi, Toyonaka, Osaka 560-0021, Japan
3 Department of Research and Development, Diagnostic Division, Otsuka Pharmaceutical Co., Ltd, Tokushima 771-0195, Japan
4 Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University, 2–2 B-5, Yamada-oka, Suita, Osaka 565-0871, Japan
BMC Nephrology 2013, 14:50 doi:10.1186/1471-2369-14-50Published: 26 February 2013
Patients on maintenance hemodialysis (HD) have much higher levels of adiponectin (Total-APN). Adiponectin and C1q form a protein complex in human blood, and serum C1q-binding adiponectin (C1q-APN) can be measured. We recently reported that C1q-APN/Total-APN ratio rather than Total-APN correlated with atherosclerosis in diabetics. However, the characteristics of C1q-APN in HD patients remain unclear. The preset study investigated the characteristics of the adiponectin parameters including C1q-APN and also to clarify the relationship between various serum adiponectin parameters and atherosclerotic cardiovascular diseases (ACVD) in HD patients.
The single cross-sectional study subjects were 117 Japanese patients (males/females = 61/56) on regular HD. Blood Total-APN, high molecular weight-adiponectin (HMW-APN), C1q-APN and C1q concentrations were measured by enzyme-linked immunosorbent assays. ACVD were defined as stroke, coronary and peripheral artery diseases, thoracic and abdominal aneurysms.
Stepwise regression analysis identified high-density lipoprotein-cholesterol (HDL-C) as the only significant and independent determinant of C1q-APN in males, and duration of HD as the only significant and independent determinant of C1q-APN in females. Stepwise regression analysis identified uric acid, low-density lipoprotein-cholesterol and triglyceride as significant and independent determinants of C1q-APN/Total-APN ratio in males, and leukocyte count and HDL-C as significant and independent determinants of C1q-APN/Total-APN ratio in females. Multiple logistic regression analysis identified inorganic phosphorus and C1q-APN or C1q-APN/C1q ratio as significant determinants of ACVD.
Low serum C1q-APN and C1q-APN/C1q ratio, but not C1q-APN/Total-APN ratio, correlated with ACVD in HD patients.