PC2 trafficking to the PM depends on intracellular Ca2+ signaling and Ca2+-dependent kinases. (A-B) Quantitative analysis of PM PC2-positive rPT cells following treatment with 100 μM ouabain with 100 μM 2-APB (A), with 10 μM BAPTA (B), or with 10 μM KN-93, 10 μM LY294002, 5 μM wortmanin, 20 nM FK506, 1 μM Go6983, 5 μM calphostin, or 100 μM cycloheximide (C). Values are the mean ± SEM, ***P < 0.001 vs. control, and #P < 0.001 vs. treatment.
Miyakawa et al. BMC Nephrology 2013 14:34 doi:10.1186/1471-2369-14-34