Reasearch Awards nomination

Email updates

Keep up to date with the latest news and content from BMC Nephrology and BioMed Central.

Open Access Highly Accessed Research article

Diastolic function is a strong predictor of mortality in patients with chronic kidney disease

Ahmad Farshid1*, Rajeev Pathak1, Bruce Shadbolt24, Leonard Arnolda14 and Girish Talaulikar34

Author Affiliations

1 Cardiology Unit, The Canberra Hospital, PO Box 11, Woden, ACT 2605, Australia

2 Centre for Advances in Epidemiology and Information Technology, The Canberra Hospital, Canberra, Australia

3 Renal Unit, The Canberra Hospital, Canberra, Australia

4 Australian National University, Canberra, Australia

For all author emails, please log on.

BMC Nephrology 2013, 14:280  doi:10.1186/1471-2369-14-280

Published: 23 December 2013

Abstract

Background

Cardiovascular disease is a major cause of death in patients with stage 4–5 Chronic Kidney disease (CKD, eGFR < 30). There are only limited data on the risk factors predicting these complications in CKD patients. Our aim was to determine the role of clinical and echocardiographic parameters in predicting mortality and cardiovascular complications in CKD patients.

Methods

We conducted a prospective observational cohort study of 153 CKD patients between 2007 and 2009. All patients underwent echocardiography at baseline and were followed for a mean of 2.6 years using regular clinic visits and review of files and hospital presentations to record the incidence of cardiovascular events and death.

Results

Of 153 patients enrolled, 57 (37%) were on dialysis and 45 (78%) of these patients were on haemodialysis. An enlarged LV was present in 32% of patients and in 22% the LVEF was below 55%. LV mass index was increased in 75% of patients. Some degree of diastolic dysfunction was present in 85% of patients and 35% had grade 2 or higher diastolic dysfunction. During follow up 41 patients (27%) died, 15 (39%) from cardiovascular causes. Mortality was 24.0% in the non-dialysis patients versus 31.6% in patients on dialysis (p=ns). On multivariate analysis age >75 years, previous history of MI, diastolic dysfunction and detectable serum troponin T were significant independent predictor of mortality (P < 0.01).

Conclusion

Patients with stage 4–5 CKD had a mortality rate of 27% over a mean follow up of 2.6 years. Age >75 years, history of MI, diastolic dysfunction and troponin T were independent predictors of mortality.

Keywords:
Chronic kidney disease; Echocardiography; Diastolic function; Cardiovascular disease; Troponin T