Table 3

Side-effects of medications
Fixed-effects model Random-effects model Heterogeneity
RR (95% CI) P value RR (95% CI) P value P value I2 (%)
Vomiting 1.06 [0.91, 1.23] 0.45 1.22 [0.81, 1.84] 0.33 0.04 54%
  LC vs Placebo 2.35 [0.95, 5.80] 0.06 1.87 [0.55, 6.37] 0.32 0.22 32%
  LC vs CBBs 1.51 [1.08, 2.12] 0.02 1.51 [1.08, 2.11] 0.02 0.37 0%
  LC vs previous phosphate binders 0.90 [0.76, 1.06] 0.20 0.90 [0.76, 1.06] 0.20 - -
Diarrhea 0.79 [0.68, 0.93] 0.003 0.69 [0.40, 1.18] 0.17 0.001 70%
  LC vs Placebo 0.31 [0.15, 0.65] 0.002 0.29 [0.14, 0.62] 0.001 0.53 0%
  LC vs CBBs 1.29 [0.84, 1.98] 0.24 1.29 [0.84, 1.98] 0.24 - -
  LC vs previous phosphate binders 0.75 [0.63, 0.90] 0.001 0.75 [0.63, 0.90] 0.001 - -
Nausea 1.03 [0.91, 1.17] 0.61 1.25 [0.85, 1.84] 0.26 0.06 52%
  LC vs Placebo 2.06 [0.82, 5.16] 0.12 1.60 [0.49, 5.16] 0.43 0.26 27%
  LC vs CBBs 1.42 [1.01, 2.01] 0.05 1.80 [0.70, 4.64] 0.22 0.09 66%
  LC vs previous phosphate binders 0.93 [0.81, 1.07] 0.32 0.93 [0.81, 1.07] 0.32 - -
Constipation 0.72 [0.46, 1.12] 0.14 0.70 [0.36, 1.35] 0.29 0.23 31%
Hypercalcaemia 0.10 [0.06, 0.16] <0.00001 0.12 [0.04, 0.38] 0.0002 0.009 71%
  LC vs CBBs
Intradialytichypotension 0.70 [0.58, 0.85] 0.0004 0.72 [0.54, 0.96] 0.03 0.28 21%
  LC vs Placebo 3.10 [0.34, 28.17] 0.31 3.10 [0.34, 28.17] 0.31 - -
  LC vs CBBs 0.83 [0.51, 1.36] 0.47 0.83 [0.51, 1.36] 0.47 - -
  LC vs previous phosphate binders 0.66 [0.53, 0.82] 0.0002 0.66 [0.53, 0.82] 0.0002 - -
Cramps or Myalgia 0.81 [0.68, 0.97] 0.02 0.83 [0.65, 1.07] 0.15 0.32 13%
  LC vs Placebo 1.29 [0.38, 4.35] 0.68 1.29 [0.38, 4.35] 0.68 - -
  LC vs CBBs 1.12 [0.64, 1.95] 0.69 1.12 [0.64, 1.95] 0.69 - -
  LC vs NCBs 0.76 [0.63, 0.92] 0.005 0.76 [0.63, 0.92] 0.005 - -
Abdominal pain 0.75 [0.61, 0.92] 0.006 0.74 [0.60, 0.91] 0.004 0.64 0%
  LC vs Placebo 2.14 [0.40, 11.44] 0.37 1.93 [0.35, 10.55] 0.45 0.56 0%
  LC vs CBBs 0.60 [0.18, 2.00] 0.40 0.60 [0.18, 2.00] 0.40 - -
  LC vs previous phosphate binders 0.73 [0.59, 0.91] 0.004 0.73 [0.59, 0.91] 0.004 - -
Bronchitis 0.82 [0.66, 1.03] 0.08 0.82 [0.66, 1.03] 0.08 0.97 0%
Dyspepsia 0.24 [0.09, 0.61] 0.003 0.21 [0.04, 1.17] 0.007 0.13 52%
  LC vs Placebo
Rhinitis 1.20 [0.69, 2.08] 0.52 1.20 [0.69, 2.08] 0.52 0.64 0%
Pruritus 4.04 [0.56, 29.27] 0.17 3.84 [0.48, 30.48] 0.20 0.55 0%
  LC vs Placebo
Dialysis complication 0.68 [0.39, 1.17] 0.16 0.67 [0.38, 1.16] 0.15 0.39 0%

Zhang et al.

Zhang et al. BMC Nephrology 2013 14:226   doi:10.1186/1471-2369-14-226

Open Data